法国儿童接种七价肺炎球菌疫苗前后19A血清型肺炎链球菌分离株的群体概况。
Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children.
作者信息
Mahjoub-Messai Farah, Doit Catherine, Koeck Jean-Louis, Billard Typhaine, Evrard Bénédicte, Bidet Philippe, Hubans Christine, Raymond Josette, Levy Corinne, Cohen Robert, Bingen Edouard
机构信息
Service de Microbiologie, Hôpital Robert-Debré (APHP), 75019 Paris, France.
出版信息
J Clin Microbiol. 2009 Mar;47(3):837-40. doi: 10.1128/JCM.01547-08. Epub 2008 Dec 24.
Abstract
Serotype 19A Streptococcus pneumoniae strains are now more frequent in French children than before the introduction of a seven-valent conjugate vaccine (PCV7). By applying multilocus sequence typing to 144 serotype 19A isolates collected before and after beginning PCV7 vaccination, we detected clonal expansion of the preexisting penicillin-intermediate sequence type 276.
摘要
19A 血清型肺炎链球菌菌株在法国儿童中现比七价结合疫苗（PCV7）引入之前更为常见。通过对PCV7疫苗接种前后收集的144株19A血清型分离株进行多位点序列分型，我们检测到先前存在的青霉素中介序列型276的克隆性扩增。
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