ISAS-Institute for Analytical Sciences, Department of Metabolomics, Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany.
J Breath Res. 2009 Sep;3(3):034001. doi: 10.1088/1752-7155/3/3/034001. Epub 2009 May 15.
Recently, ion mobility spectrometry (IMS) started to be used for direct breath analysis with respect to metabolic profiling, biomarker finding and gas trace analysis. The present review describes the basic operation of an ion mobility spectrometer including the ionization process, humidity effects and sampling procedures. To enhance the resolution, pre-separation by multi-capillary columns (MCCs) is discussed and examples for IMS chromatograms are presented. The focus is to review the analytical method IMS with respect to potential use for direct investigations of humid air in direct breath analysis but not on detailed discussion of results of specific medical application of MCC/IMS or on specific analytes found in exhaled air.
最近，离子迁移谱（IMS）开始用于直接呼吸分析，涉及代谢组学、生物标志物发现和气体痕量分析。本综述描述了离子迁移谱仪的基本操作，包括电离过程、湿度影响和采样程序。为了提高分辨率，讨论了多毛细管柱（MCC）的预分离，并展示了 IMS 色谱图的示例。重点是回顾分析方法 IMS，探讨其在直接呼吸分析中直接研究潮湿空气的潜在用途，但不详细讨论 MCC/IMS 在特定医学应用中的结果或在呼出空气中发现的特定分析物。
