Department of Anesthesiology, College of Medicine, University of Kentucky, Lexington, USA.
J Investig Med. 2011 Jun;59(5):768-79. doi: 10.2310/JIM.0b013e31821452bf.
Accelerating the translation of new scientific discoveries to improve human health and disease management is the overall goal of a series of initiatives integrated in the National Institutes of Health (NIH) "Roadmap for Medical Research." The Clinical and Translational Science Award (CTSA) program is, arguably, the most visible component of the NIH Roadmap providing resources to institutions to transform their clinical and translational research enterprises along the goals of the Roadmap. The CTSA program emphasizes biomedical informatics as a critical component for the accomplishment of the NIH's translational objectives. To be optimally effective, emerging biomedical informatics programs must link with the information technology platforms of the enterprise clinical operations within academic health centers.This report details one academic health center's transdisciplinary initiative to create an integrated academic discipline of biomedical informatics through the development of its infrastructure for clinical and translational science infrastructure and response to the CTSA mechanism. This approach required a detailed informatics strategy to accomplish these goals. This transdisciplinary initiative was the impetus for creation of a specialized biomedical informatics core, the Center for Biomedical Informatics (CBI). Development of the CBI codified the need to incorporate medical informatics including quality and safety informatics and enterprise clinical information systems within the CBI. This article describes the steps taken to develop the biomedical informatics infrastructure, its integration with clinical systems at one academic health center, successes achieved, and barriers encountered during these efforts.
加速将新的科学发现转化为改善人类健康和疾病管理的成果是一系列整合在国立卫生研究院（NIH）“医学研究路线图”中的倡议的总体目标。临床和转化科学奖（CTSA）计划可以说是 NIH 路线图中最引人注目的组成部分，它为机构提供资源，使其临床和转化研究业务沿着路线图的目标转变。CTSA 计划强调生物医学信息学作为实现 NIH 转化目标的关键组成部分。为了实现最佳效果，新兴的生物医学信息学计划必须与学术医疗中心的企业临床运营的信息技术平台相连接。本报告详细介绍了一个学术医疗中心通过开发其临床和转化科学基础设施的基础设施以及对 CTSA 机制的响应，创建一个综合的生物医学信息学学科的跨学科举措。这种方法需要一个详细的信息学策略来实现这些目标。这种跨学科的举措是创建一个专门的生物医学信息学核心机构，即生物医学信息学中心（CBI）的动力。CBI 的发展规定了需要将医疗信息学（包括质量和安全信息学以及企业临床信息系统）纳入 CBI 中。本文描述了在一个学术医疗中心开发生物医学信息学基础设施及其与临床系统集成的步骤、取得的成功以及在这些努力中遇到的障碍。
