Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Nat Med. 2011 Mar;17(3):320-9. doi: 10.1038/nm.2328.
Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.
肿瘤就像新器官一样，由多种细胞类型和成分组成。肿瘤与正常微环境竞争，以克服抗肿瘤压力。在这场战斗取得胜利之前，肿瘤可能潜伏在器官中而不被宿主察觉，这种情况被称为“隐匿性癌症”。我们回顾了正常组织的稳态和结构如何抑制癌症的进展，以及微环境的变化如何改变这些信号的平衡，使其向致癌状态倾斜。我们还讨论了如何将这些信息应用于临床实践。
