黑种草籽油对甲状腺功能减退大鼠应激性胃炎形成的胃保护作用。
Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats.
作者信息
Abdel-Sater Khaled A
机构信息
Department of Physiology, Faculty of Medicine for Boys, Al-Azhar University Assiut branch Assiut, Egypt.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2009 Mar 10;1(2):143-149.
Abstract
The aim of this study was to assess the effects of hypothyroidism on the development of acute cold restraint stress gastritis in rats and protective effect of Nigella sativa at the beginning of the acute cold restraint stress. 60 rats were randomly divided into six groups; the control (groups I), surgically thyroidectomized group (group II), acute cold restraint stressed group (group III), surgically thyroidectomized plus stressed group (group IV), Nigella sativa oil group (group V) and surgically thyroidectomized plus stressed plus Nigella sativa oil group (group VI). Volume of gastric juice, number and size of ulcer, gastric malonaldehyde, gastric glutathione, gastric protein and serum thyroxine (T4) were measured. Significant increases both of number of gastric ulcer and malonaldehyde while decreases both of glutathione and protein levels in rats in groups III and IV in comparison with control group. While, insignificant increase were observed between control and both of groups II and VI. In rats, low thyroid hormone level increase stress gastritis, and this effect can be decreased by treatment with Nigella sativa.
摘要
本研究旨在评估甲状腺功能减退对大鼠急性冷束缚应激性胃炎发展的影响以及黑种草在急性冷束缚应激开始时的保护作用。60只大鼠随机分为六组：对照组（I组）、手术切除甲状腺组（II组）、急性冷束缚应激组（III组）、手术切除甲状腺加应激组（IV组）、黑种草油组（V组）和手术切除甲状腺加应激加黑种草油组（VI组）。测量胃液量、溃疡数量和大小、胃丙二醛、胃谷胱甘肽、胃蛋白和血清甲状腺素（T4）。与对照组相比，III组和IV组大鼠的胃溃疡数量和丙二醛均显著增加，而谷胱甘肽和蛋白水平均降低。同时，II组和VI组与对照组之间观察到无显著增加。在大鼠中，低甲状腺激素水平会增加应激性胃炎，而黑种草治疗可降低这种影响。
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