Amirkia Vafa David, Qiubao Pan
TOKU-E Company, Research and Development Division, 150 Cecil St. #16-00, Singapore 069543.
Bioinformation. 2011 Jan 22;5(8):365-6. doi: 10.6026/97320630005365.
Although the ever-growing usage of antimicrobials in the fields of medicine, pharmacology, and microbiology have undoubtedly allowed for unprecedented advances in the scientific world, these advances are nevertheless accompanied by unprecedented challenges. Sharp increases in antibiotic usages have led to inefficient and wasteful usage practices. Bacterial resistances have dramatically increased and therefore hindered the effectiveness of traditional antibiotics, thus forcing many life-science professionals to turn to plant extracts and synthetic chemicals [1]. The Antimicrobial Index (TAMI) seeks to alleviate some of these mounting difficulties through the collection and centralization of relevant antimicrobial susceptibility data from journals. Data compiled for antimicrobials include: method of action, physical properties, resistance genes, side effects, and minimal inhibitory concentrations (MIC50, MIC90 and/or ranges). TAMI currently contains data on 960 antimicrobials and over 24,000 microorganisms (3,500 unique strains) which were collected from over 400 pieces of published literature. Volume and scope of the index have been and will continue to increase and it is hoped that such an index will further foster international cooperation and communication of antimicrobial-related knowledge. TAMI can be accessed at: http://antibiotics.toku-e.com/.
尽管抗菌药物在医学、药理学和微生物学领域的使用不断增加，无疑推动了科学界取得前所未有的进展，但这些进展也伴随着前所未有的挑战。抗生素使用量的急剧增加导致了低效和浪费的使用方式。细菌耐药性大幅上升，从而阻碍了传统抗生素的有效性，这迫使许多生命科学专业人员转向植物提取物和合成化学品[1]。抗菌药物索引（TAMI）旨在通过从期刊收集和集中相关抗菌药敏数据来缓解其中一些日益增加的困难。为抗菌药物汇编的数据包括：作用方式、物理性质、耐药基因、副作用和最低抑菌浓度（MIC50、MIC90和/或范围）。TAMI目前包含从400多篇已发表文献中收集的960种抗菌药物和超过24000种微生物（3500种独特菌株）的数据。该索引的规模和范围已经并将继续扩大，希望这样一个索引将进一步促进抗菌相关知识的国际合作与交流。可通过以下网址访问TAMI：http://antibiotics.toku-e.com/ 。
