Lissoni P, Barni S, Rovelli F, Viviani S, Maestroni G J, Conti A, Tancini G
Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, Milano, Italy.
Eur J Cancer. 1990 Jan;26(1):33-6. doi: 10.1016/0277-5379(90)90253-p.
In an attempt to further understand the biological significance of soluble IL-2 receptors (sIL-2R) in solid tumors, we have evaluated 160 cancer patients (breast: 40; lung: 66; colon: 18; stomach: 22; uterine cervix: 14) and 58 healthy subjects, as controls. Serum mean levels of sIL-2R, measured with an enzyme immunoassay, were significantly higher in cancer patients than in controls. Metastatic cancer patients showed significantly higher values than the non-metastatic ones; this difference was significant in all tumor histotypes, except small cell lung carcinoma. Moreover, in 15 patients in whom sIL-2R were evaluated either before or after radical surgery, a significant surgery-induced increase in sIL-R mean values was seen. Finally, the chemotherapy-induced rise in sIL-2R appeared to be associated with a lack of clinical response. These results seem to suggest that sIL-2R may be a marker of host biological response in patients with solid tumors, the significance of which needs further investigation.
为了进一步了解可溶性白细胞介素-2受体（sIL-2R）在实体瘤中的生物学意义，我们评估了160例癌症患者（乳腺癌：40例；肺癌：66例；结肠癌：18例；胃癌：22例；子宫颈癌：14例）以及58名健康受试者作为对照。采用酶免疫测定法测得的癌症患者血清sIL-2R平均水平显著高于对照组。转移性癌症患者的值显著高于非转移性患者；除小细胞肺癌外，所有肿瘤组织学类型中这种差异均显著。此外，在15例接受根治性手术前后评估sIL-2R的患者中，观察到手术导致sIL-2R平均值显著升高。最后，化疗引起的sIL-2R升高似乎与缺乏临床反应相关。这些结果似乎表明，sIL-2R可能是实体瘤患者宿主生物学反应的一个标志物，其意义有待进一步研究。
