Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
J Agric Food Chem. 2011 Apr 27;59(8):4192-7. doi: 10.1021/jf104812g. Epub 2011 Mar 8.
The effect of silk protein with different fibroin/sericin compositions on body weight and lipid metabolism in high fat-fed mice was investigated. The animals were given experimental diets for 6 weeks: normal control (NC), high fat (HF) and high fat diet supplemented with F100 (pure fibroin, HF-F100), F81 (81:19 fibroin/sericin, w/w, HF-F81) or F50 (50:50 fibroin/sericin, w/w, HF-F50). The silk protein-fed mice showed markedly reduced body weight and enhanced lipid profile relative to the HF group. In general, the amount of body fat, triglyceride and total plasma cholesterol levels, atherogenic index and free fatty acid level tended to decrease, while the HDL-cholesterol level increased, with increased amount of sericin in the diet. This hypolipidemic effect was partly due to increased fecal lipid excretion, inhibition of lipogenesis and regulation of adipokine production. These findings illustrate that silk protein, particularly sericin, may be beneficial in the prevention of high fat diet-induced hyperlipidemia and obesity.
研究了不同丝素/丝胶组成的丝蛋白对高脂饮食喂养小鼠体重和脂代谢的影响。动物给予实验性饮食 6 周：正常对照组（NC）、高脂组（HF）和高脂饮食添加 F100（纯丝素，HF-F100）、F81（81:19 丝素/丝胶，w/w，HF-F81）或 F50（50:50 丝素/丝胶，w/w，HF-F50）组。与 HF 组相比，摄入丝蛋白的小鼠体重明显减轻，血脂谱得到改善。总的来说，体脂、甘油三酯和总血浆胆固醇水平、动脉粥样硬化指数和游离脂肪酸水平趋于降低，而高密度脂蛋白胆固醇水平升高，饮食中丝胶的含量增加。这种降血脂作用部分归因于粪便中脂质排泄增加、脂肪生成抑制和脂联素产生的调节。这些发现表明，丝蛋白，特别是丝胶，可能有益于预防高脂饮食诱导的高血脂和肥胖。
