Marchiori Luciana Lozza de Moraes, Doi Marcelo Yugi, Marchiori Glória de Moraes, de Souza Glenda Ventura, Poli-Frederico Regina Célia, Ciquinato Daiane Soares de Almeida
Pitágoras/Unopar, Londrina, Paraná; Centro Universitário de Maringá Unicesumar, Maringá, Paraná, Brazil.
Pitágoras/Unopar, Londrina, Paraná, Brazil.
Noise Health. 2019 Mar-Apr;21(99):77-82. doi: 10.4103/nah.NAH_67_18.
To investigate the association between the single nucleotide polymorphism in the position-889 (C/T) of the promoter region of the IL-1α gene and the susceptibility to tinnitus.
This was a case-control study with a sample of 108 independent elderly people over 60 years of age. Information on exposure to occupational noise and tinnitus was obtained by interviews. The genetic polymorphism was analyzed by polymerase chain reaction followed by cleavage with restriction enzyme NcoI. Data were analyzed using the Chi-square test, with the significance level set at 5%. For the statistical analysis all individuals with tinnitus on the right ear were eligible.
Among elderly with tinnitus, 42.9% had a history of exposure to occupational noise. There was statistically significant association between IL-1α gene polymorphism and tinnitus in subjects without a history of exposure to occupational noise (P = 0.006 and χ = 10.39). The elderly with the T allele were less likely to have tinnitus due to occupational noise exposure when compared to those carrying the C allele.
This study suggests an association between the IL-1α gene polymorphism with susceptibility to tinnitus in individuals without a history of exposure to occupational noise. The present study demonstrated that allele T of IL-1α is a protective factor for presence and severity of tinnitus in the elderly and allele C contributes to the pathogenesis of the inflammatory response. The present observation implied the signaling IL-1α is involved in ear aging.
探讨白细胞介素-1α（IL-1α）基因启动子区第889位（C/T）单核苷酸多态性与耳鸣易感性之间的关联。
这是一项病例对照研究，样本为108名60岁以上的独立老年人。通过访谈获取职业噪声暴露和耳鸣的信息。采用聚合酶链反应继以限制性内切酶NcoI切割的方法分析基因多态性。使用卡方检验分析数据，显著性水平设定为5%。所有右耳有耳鸣的个体均纳入统计分析。
耳鸣老年人中，42.9%有职业噪声暴露史。在无职业噪声暴露史的受试者中，IL-1α基因多态性与耳鸣之间存在统计学显著关联（P = 0.006，χ = 10.39）。与携带C等位基因的老年人相比，携带T等位基因的老年人因职业噪声暴露而患耳鸣的可能性较小。
本研究提示，在无职业噪声暴露史的个体中，IL-1α基因多态性与耳鸣易感性之间存在关联。本研究表明，IL-1α的T等位基因是老年人耳鸣发生和严重程度的保护因素，而C等位基因则促成炎症反应的发病机制。本观察结果提示IL-1α信号通路参与了耳部衰老过程。
