Human Virology Department, Inserm U758, Ecole Normale Superieure de Lyon, 36 Allee d'Italie, IFR128, Universite de Lyon, Lyon, France.
Retrovirology. 2011 Mar 7;8:15. doi: 10.1186/1742-4690-8-15.
Retroviruses are enveloped viruses that assemble on the inner leaflet of cellular membranes. Improving biophysical techniques has recently unveiled many molecular aspects of the interaction between the retroviral structural protein Gag and the cellular membrane lipids. This interaction is driven by the N-terminal matrix domain of the protein, which probably undergoes important structural modifications during this process, and could induce membrane lipid distribution changes as well. This review aims at describing the molecular events occurring during MA-membrane interaction, and pointing out their consequences in terms of viral assembly. The striking conservation of the matrix membrane binding mode among retroviruses indicates that this particular step is most probably a relevant target for antiviral research.
逆转录病毒是有包膜的病毒，它们在细胞膜的内层组装。最近，改进的生物物理技术揭示了逆转录病毒结构蛋白 Gag 与细胞膜脂质之间相互作用的许多分子方面。这种相互作用是由蛋白质的 N 端基质结构域驱动的，该结构域在这个过程中可能会发生重要的结构修饰，并可能诱导膜脂质分布的变化。本综述旨在描述 MA 与膜相互作用过程中发生的分子事件，并指出它们在病毒组装方面的后果。逆转录病毒之间基质膜结合模式的惊人保守性表明，这一特殊步骤很可能是抗病毒研究的一个重要目标。
