Brunet F, Vedel G, Dreyfus F, Vaxelaire J F, Giraud T, Schremmer B, Monsallier J F
Service de Réanimation, Cochin University Hospital, Paris, France.
Eur J Clin Microbiol Infect Dis. 1990 Feb;9(2):145-7. doi: 10.1007/BF01963643.
A report is given on two neutropenic patients with staphylococcal septicemia caused by Staphylococcus haemolyticus and Staphylococcus aureus (both strains methicillin-resistant) who failed to respond to therapy with teicoplanin. Both strains were resistant to teicoplanin (MIC 16 and 8 mg/l respectively), but remained sensitive to vancomycin (MIC 2 and 4 mg/l respectively). Replacement of teicoplanin with vancomycin led to full recovery of both patients and their discharge from hospital. These two cases emphasize the importance of clinical and microbiological monitoring of patients with staphylococcal septicemia, even when glycopeptides are used for treatment.
报告了两例中性粒细胞减少患者，他们分别由溶血葡萄球菌和金黄色葡萄球菌（两种菌株均耐甲氧西林）引起葡萄球菌败血症，对替考拉宁治疗无反应。两种菌株均对替考拉宁耐药（MIC分别为16和8mg/L），但对万古霉素仍敏感（MIC分别为2和4mg/L）。用万古霉素替代替考拉宁后，两名患者均完全康复并出院。这两例病例强调了对葡萄球菌败血症患者进行临床和微生物学监测的重要性，即使在使用糖肽类药物进行治疗时也是如此。
