Carper H T, Sullivan G W, Mandell G L
J Antimicrob Chemother. 1987 May;19(5):659-62. doi: 10.1093/jac/19.5.659.
Groups of mice infected with 3.3 X 10(8) Staphylococcus aureus via the tail vein were treated three days later with rifampicin (13 mg/kg), vancomycin (33 mg/kg), or teicoplanin (33 mg/kg). Rifampicin was the most effective agent (28 out of 29 survivors). Vancomycin and teicoplanin were of equivalent efficacy (21 of 29 and 24 of 29 survivors, respectively). When intraleucocytic staphylococci were incubated with rifampicin (1 or 20 mg/l), vancomycin (100 mg/l), or teicoplanin (100 mg/l), rifampicin was the most active drug. Vancomycin and teicoplanin were similar.
通过尾静脉感染3.3×10⁸金黄色葡萄球菌的小鼠组，在三天后分别用利福平（13毫克/千克）、万古霉素（33毫克/千克）或替考拉宁（33毫克/千克）进行治疗。利福平是最有效的药物（29只小鼠中有28只存活）。万古霉素和替考拉宁的疗效相当（分别为29只中有21只和24只存活）。当将细胞内葡萄球菌与利福平（1或20毫克/升）、万古霉素（100毫克/升）或替考拉宁（100毫克/升）一起孵育时，利福平是活性最强的药物。万古霉素和替考拉宁相似。
