Stamatis Pavlos
Department of Clinical Sciences, Rheumatology, Lund University, Sweden.
Mediterr J Rheumatol. 2020 Jun 30;31(2):174-182. doi: 10.31138/mjr.31.2.174. eCollection 2020 Jun.
Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or are age-associated different clinical phenotypes of the same disease. On the other hand, there are differences regarding epidemiology, several clinical features (eg, polymyalgia rheumatica in GCA) and treatment. The aim of this review is to present the latest data regarding this question and to shed some light on the differences and similarities between GCA and TAK regarding epidemiology, genetics, pathogenesis, histopathology, clinical presentation, imaging and treatment. The existing data in literature support the opinion that GCA and TAK are different clinical entities.
巨细胞动脉炎（GCA）和大动脉炎（TAK）是两种影响中、大动脉的系统性肉芽肿性血管炎。在过去十年中，GCA和TAK在临床表现、全身炎症反应以及动脉病变分布方面的相似性引发了一场争论，即GCA和TAK是两种不同的疾病，还是同一疾病与年龄相关的不同临床表型。另一方面，在流行病学、一些临床特征（如GCA中的风湿性多肌痛）和治疗方面存在差异。本综述的目的是介绍有关这个问题的最新数据，并阐明GCA和TAK在流行病学、遗传学、发病机制、组织病理学、临床表现、影像学和治疗方面的异同。文献中的现有数据支持GCA和TAK是不同临床实体的观点。
