巨细胞动脉炎与高安动脉炎：最新进展
Giant Cell Arteritis versus Takayasu Arteritis: An Update.
作者信息
Stamatis Pavlos
机构信息
Department of Clinical Sciences, Rheumatology, Lund University, Sweden.
出版信息
Mediterr J Rheumatol. 2020 Jun 30;31(2):174-182. doi: 10.31138/mjr.31.2.174. eCollection 2020 Jun.
Abstract
Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or are age-associated different clinical phenotypes of the same disease. On the other hand, there are differences regarding epidemiology, several clinical features (eg, polymyalgia rheumatica in GCA) and treatment. The aim of this review is to present the latest data regarding this question and to shed some light on the differences and similarities between GCA and TAK regarding epidemiology, genetics, pathogenesis, histopathology, clinical presentation, imaging and treatment. The existing data in literature support the opinion that GCA and TAK are different clinical entities.
摘要
巨细胞动脉炎（GCA）和大动脉炎（TAK）是两种影响中、大动脉的系统性肉芽肿性血管炎。在过去十年中，GCA和TAK在临床表现、全身炎症反应以及动脉病变分布方面的相似性引发了一场争论，即GCA和TAK是两种不同的疾病，还是同一疾病与年龄相关的不同临床表型。另一方面，在流行病学、一些临床特征（如GCA中的风湿性多肌痛）和治疗方面存在差异。本综述的目的是介绍有关这个问题的最新数据，并阐明GCA和TAK在流行病学、遗传学、发病机制、组织病理学、临床表现、影像学和治疗方面的异同。文献中的现有数据支持GCA和TAK是不同临床实体的观点。
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本文引用的文献
1
Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis.大动脉炎的治疗：一项系统文献综述，为 2018 年 EULAR 大血管血管炎治疗建议的更新提供信息。
RMD Open. 2019 Sep 23;5(2):e001020. doi: 10.1136/rmdopen-2019-001020. eCollection 2019.
2
Clinical symptoms and associated vascular imaging findings in Takayasu's arteritis compared to giant cell arteritis.与巨细胞动脉炎相比，Takayasu 动脉炎的临床症状及相关血管影像学表现。
Ann Rheum Dis. 2020 Feb;79(2):262-267. doi: 10.1136/annrheumdis-2019-216145. Epub 2019 Oct 24.
3
Patterns of Arterial Disease in Takayasu Arteritis and Giant Cell Arteritis.Takayasu 动脉炎和巨细胞动脉炎的动脉病变模式。
Arthritis Care Res (Hoboken). 2020 Nov;72(11):1615-1624. doi: 10.1002/acr.24055.
4
2018 Update of the EULAR recommendations for the management of large vessel vasculitis.2018 年版 EULAR 大血管血管炎管理建议更新。
Ann Rheum Dis. 2020 Jan;79(1):19-30. doi: 10.1136/annrheumdis-2019-215672. Epub 2019 Jul 3.
5
Malignancies in Giant Cell Arteritis: A Population-based Cohort Study.巨细胞动脉炎中的恶性肿瘤：一项基于人群的队列研究。
J Rheumatol. 2020 Mar;47(3):400-406. doi: 10.3899/jrheum.190236. Epub 2019 Jun 1.
6
Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets.巨细胞动脉炎：发病机制及新的潜在治疗靶点
BMC Rheumatol. 2017 Nov 28;1:2. doi: 10.1186/s41927-017-0004-5. eCollection 2017.
7
Swedish Society of Rheumatology 2018 guidelines for investigation, treatment, and follow-up of giant cell arteritis.瑞典风湿病学会 2018 年巨细胞动脉炎的调查、治疗和随访指南。
Scand J Rheumatol. 2019 Jul;48(4):259-265. doi: 10.1080/03009742.2019.1571223. Epub 2019 Mar 6.
8
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Best Pract Res Clin Rheumatol. 2018 Feb;32(1):31-51. doi: 10.1016/j.berh.2018.10.001. Epub 2018 Nov 22.
9
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Rheumatol Int. 2018 Dec;38(12):2263-2270. doi: 10.1007/s00296-018-4150-x. Epub 2018 Sep 4.
10
Overall survival and mortality risk factors in Takayasu's arteritis: A multicenter study of 318 patients.大动脉炎的总体生存和死亡风险因素：318 例患者的多中心研究。
J Autoimmun. 2019 Jan;96:35-39. doi: 10.1016/j.jaut.2018.08.001. Epub 2018 Aug 17.
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