Department of Surgery, Division of Plastic Surgery, University of Medicine and Dentistry of New Jersey, Newark, USA.
Aesthet Surg J. 2011 Mar;31(3):328-41. doi: 10.1177/1090820X11398353.
Cellulite is characterized by a thickened hypodermal fat layer, along with hypodermal fat lobules that extend upward into the dermis, expanding and stretching the fibrous septae that separate the fat lobules. Eventually, the septae sclerose, contract, and harden, holding the skin at an inflexible length while the surrounding tissue continues to expand.
The author evaluates the efficacy, safety, and duration of clinical benefit associated with a pulsed laser that delivers 1440-nm energy to the dermal-hypodermal interface for the treatment of cellulite. The changes in the dermal structure that affect the appearance of cellulite are also examined.
Ten healthy women with cellulite on their thighs enrolled in a prospective Institutional Review Board-approved study conducted in the author's private plastic surgery clinic. Patients received a single treatment with a 1440-nm pulsed laser. Energy was delivered to the subdermal tissue through a fiber that was designed for side firing and enclosed in a cannula. Treatment addressed the thickened hypodermal fat layer, hypodermal fat lobules that extended upward into the dermis, and fibrous septae by thermal subcision.
The mean age of the patients was 47 years ± 5.4 years. Mean skin thickness (as shown by ultrasound) and skin elasticity were shown by objective measurements to increase significantly at one, three, six, and 12 months. Subjective physician and subject evaluations indicated improvement, high subject satisfaction, and minimal adverse effects.
In this study, a single treatment with the 1440-nm pulsed laser improved the appearance of cellulite, an improvement that persisted through at least one year of follow-up with minimal adverse effects.
蜂窝组织炎的特征是皮下脂肪层增厚，以及皮下脂肪小叶向上延伸到真皮，扩张并拉伸分隔脂肪小叶的纤维隔。最终，隔带硬化、收缩并变硬，使皮肤保持在不可伸展的长度，而周围组织继续扩张。
作者评估了一种脉冲激光的疗效、安全性和临床获益持续时间，该激光在真皮-皮下界面输送 1440nm 能量，用于治疗蜂窝组织炎。还检查了影响蜂窝组织炎外观的真皮结构变化。
10 名大腿有蜂窝组织炎的健康女性参加了一项前瞻性机构审查委员会批准的研究，该研究在作者的私人整形诊所进行。患者接受了一次 1440nm 脉冲激光治疗。能量通过设计用于侧发射并包含在套管内的光纤输送到皮下组织。治疗通过热亚切开处理增厚的皮下脂肪层、向上延伸到真皮的皮下脂肪小叶和纤维隔带。
患者的平均年龄为 47 岁±5.4 岁。通过客观测量显示，平均皮肤厚度（如超声所示）和皮肤弹性在一个月、三个月、六个月和十二个月时显著增加。医生和患者的主观评估表明有改善，患者满意度高，不良反应最小。
在这项研究中，单次使用 1440nm 脉冲激光治疗可改善蜂窝组织炎的外观，这种改善在至少一年的随访中持续存在，不良反应最小。
