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Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs.

作者信息

Treudler Regina, Pohle Katja, Simon Jan Christoph

出版信息

Eur J Clin Pharmacol. 2011 Sep;67(9):961-3. doi: 10.1007/s00228-011-1022-7. Epub 2011 Mar 9.

DOI:10.1007/s00228-011-1022-7
PMID:21387166
Abstract
摘要

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Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs.对于对非甾体抗炎药过敏的患者，氟吡汀是一种安全的替代药物。
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2
Aspirin-intolerant chronic urticaria exacerbated by cutaneous application of a ketoprofen poultice.皮肤应用酮洛芬软膏加剧阿司匹林不耐受性慢性荨麻疹。
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Possible link between history of hypersensitivity to a specific non-steroidal anti-inflammatory drug (NSAID) and positive results following challenge test to alternative NSAIDS.对特定非甾体抗炎药（NSAID）过敏史与对替代NSAIDs激发试验阳性结果之间的可能联系。
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The safety of codeine in patients with non-steroidal anti-inflammatory drug hypersensitivity: a preliminary study.可待因在非甾体抗炎药过敏患者中的安全性：一项初步研究。
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Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?对于交叉反应性非甾体抗炎药超敏反应患者，药物激发试验对于检测COX-2抑制剂的安全性是否仍然必要？
Allergol Immunopathol (Madr). 2013 May-Jun;41(3):181-8. doi: 10.1016/j.aller.2012.03.006. Epub 2012 Sep 30.
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Determining safe alternatives for multidrug hypersensitive patients with the alternative triple antibiotic-analgesic test.采用替代性三联抗生素-镇痛药试验为多药过敏患者确定安全的替代方案。
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Selective hypersensitivity reactions to acetaminophen: a 13-case series.对乙酰氨基酚的选择性超敏反应：13例病例系列
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Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children.药物激发试验在儿童非甾体类抗炎药过敏反应诊断中的应用。
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Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders.非甾体抗炎药诱导的皮肤疾病患者对乙酰氨基酚和尼美舒利不耐受的危险因素。
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Provocation tests with the offending nonsteroidal anti-inflammatory drugs in patients with urticaria/angioedema reactions.在荨麻疹/血管性水肿反应患者中进行致过敏的非甾体抗炎药激发试验。
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Inhibition of Spontaneous Contractility of Isolated Caprine Ureter by Flupirtine.氟吡汀对离体山羊输尿管自发收缩性的抑制作用。
Int J Appl Basic Med Res. 2018 Apr-Jun;8(2):116-119. doi: 10.4103/ijabmr.IJABMR_159_17.
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Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.氟吡汀在健康受试者中的代谢活化及镇痛作用，多态性NAT2、UGT1A1和GSTP1的影响。

本文引用的文献

1
Flupirtine in pain management: pharmacological properties and clinical use.氟吡汀在疼痛管理中的应用：药理学特性及临床用途。
CNS Drugs. 2010 Oct;24(10):867-81. doi: 10.2165/11536230-000000000-00000.
2
NSAIDs and cardiovascular disease: transducing human pharmacology results into clinical read-outs in the general population.非甾体抗炎药与心血管疾病：将人体药理学研究结果转化为普通人群的临床研究结果。
Pharmacol Rep. 2010 May-Jun;62(3):530-5. doi: 10.1016/s1734-1140(10)70310-8.
3
Selective immediate hypersensitivity reactions to NSAIDs.非甾体抗炎药的选择性即刻超敏反应。
Br J Clin Pharmacol. 2015 Mar;79(3):501-13. doi: 10.1111/bcp.12522.
4
Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.氟吡汀致肝损伤——来自柏林病例对照监测研究的 7 例病例和德国自发药物不良反应报告数据库的回顾。
Eur J Clin Pharmacol. 2014 Apr;70(4):453-9. doi: 10.1007/s00228-013-1631-4. Epub 2013 Dec 24.
5
[The association of unwanted drug effects and increased psychovegetative lability].[药物不良反应与精神植物神经易激惹性增加的关联]
Hautarzt. 2013 Jun;64(6):420-3. doi: 10.1007/s00105-012-2498-5.
6
Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years.一种已上市约 30 年的处方药物氟吡汀出现了意料之外的频繁肝毒性。
Br J Clin Pharmacol. 2012 May;73(5):821-5. doi: 10.1111/j.1365-2125.2011.04138.x.
Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):293-7. doi: 10.1097/ACI.0b013e32832db943.
4
Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound.氟吡汀：一种非阿片类镇痛药和潜在神经保护化合物的药理学和临床应用。
Expert Opin Pharmacother. 2009 Jun;10(9):1495-500. doi: 10.1517/14656560902988528.
5
Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*.氟吡汀与曲马多治疗亚急性下腰痛患者的镇痛疗效及耐受性：一项双盲多中心试验*
Curr Med Res Opin. 2008 Dec;24(12):3523-30. doi: 10.1185/03007990802579769.
6
Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature.对非甾体抗炎药（NSAIDs）不耐受患者对环氧化酶-2选择性抑制剂（coxibs）的耐受性：文献的系统结构化综述
Arch Dermatol Res. 2007 Jul;299(4):169-75. doi: 10.1007/s00403-007-0757-6. Epub 2007 May 11.
7
Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease.功能性N-甲基-D-天冬氨酸拮抗剂氟吡汀对帕金森病自动姿势反应的影响。
J Neurol. 2002 Jul;249(7):824-8. doi: 10.1007/s00415-002-0727-z.