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[药物不良反应与精神植物神经易激惹性增加的关联]

[The association of unwanted drug effects and increased psychovegetative lability].

作者信息

Seikowski K, Barth D, Majer A, Treudler R

机构信息

Klinik für Psychosomatische Medizin und Psychotherapie, Psychosomatische Dermatologie und Urologie, Universität Leipzig, Semmelweisstr. 10, 04103 Leipzig, Deutschland.

出版信息

Hautarzt. 2013 Jun;64(6):420-3. doi: 10.1007/s00105-012-2498-5.

DOI:10.1007/s00105-012-2498-5
PMID:23677540
Abstract

OBJECTIVE

Based on a history of unwanted drug effects, patients had to undergo a series of exposure tests to identify alternative non-invasive drugs. In our study we examined if psychosomatic factors (in the sense of psychovegetative lability) occurred more frequently in patients with unwanted drug effects.

METHODS

For this purpose, 91 patients filled out a series of questionnaires for the assessment of mental factors. The questionnaires used were the BEB (a questionnaire for the assessment of psychosomatic complaints), the TICS questionnaire (Trierer questionnaire of chronic stress), the scale "critical life events" of LRF-LE and the anxiety questionnaire "STAI".

RESULTS

All scales which were used for the assessment of the psychosomatic complaint status (BEB) showed increased values. Chronic stress factors (TICS) and anxiety (STAI) did not play a role. Critical life events occurred more often.

CONCLUSION

The occurrence of unwanted drug effects is associated with psychosomatic complaints and acute critical life events. This enables the patient to get a complex understanding for the explanation of the complaints.

摘要

目的

基于不良药物反应史,患者必须接受一系列暴露试验以确定替代性非侵入性药物。在我们的研究中,我们考察了具有不良药物反应的患者中的心身因素(从心理植物性不稳定的意义上来说)是否更频繁出现。

方法

为此,91名患者填写了一系列用于评估心理因素的问卷。所使用的问卷有BEB(一份用于评估心身症状的问卷)、TICS问卷(特里尔慢性应激问卷)、LRF-LE的“重大生活事件”量表以及焦虑问卷“STAI”。

结果

所有用于评估心身症状状态的量表(BEB)显示数值升高。慢性应激因素(TICS)和焦虑(STAI)不起作用。重大生活事件更频繁发生。

结论

不良药物反应的发生与心身症状和急性重大生活事件相关。这使得患者能够对症状的解释有一个全面的理解。

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Chem Immunol Allergy. 2012;97:98-105. doi: 10.1159/000335621. Epub 2012 May 3.
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Patient-doctor interaction, psychobehavioural characteristics and mental disorders in patients with suspected allergies: do they predict "medically unexplained symptoms"?疑似过敏患者的医患互动、心理行为特征和精神障碍:它们能否预测“无法解释的医学症状”?
Acta Derm Venereol. 2011 Oct;91(6):666-73. doi: 10.2340/00015555-1147.
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Magical thinking in somatoform disorders: an exploratory study among patients with suspected allergies.躯体形式障碍中的魔幻思维:一项针对疑似过敏患者的探索性研究。
Psychopathology. 2011;44(5):283-8. doi: 10.1159/000322795. Epub 2011 Jun 9.
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High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria.慢性自发性荨麻疹患者精神障碍和情绪困扰的高发率。
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