Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Clin Nutr. 2011 Aug;30(4):503-5. doi: 10.1016/j.clnu.2011.01.016. Epub 2011 Mar 8.
BACKGROUND & AIMS: The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells.
The FA composition has been analyzed with a micromethod in 16 triplets, including maternal blood, cord blood at delivery and infant blood at day 4, respectively.
As expected, the FA composition of blood samples withdrawn from the umbilical cord is more similar to the FA composition of blood from 4-day old infants than the FA pattern of maternal blood at delivery. Nevertheless, infant blood FA profile differed from cord for lower long-chain polyunsaturated FA and higher monounsaturated FA.
Our explorative data using whole blood microanalysis confirm the progressive increase of long-chain polyunsaturated FA levels from the mothers towards cord and then infant blood.
脂肪酸（FA）在围产期的生物学作用正受到广泛研究。本研究应用简化的微分析方法，比较了母体、脐血和婴儿全血的 FA 谱，包括所有循环脂质和细胞。
采用微量法分析了 16 对母婴脐血和婴儿生后 4 天的血液样本。
与预期一致，脐血的 FA 组成与 4 天婴儿的血液 FA 组成更为相似，而与分娩时母体血液的 FA 模式不同。然而，婴儿血液的 FA 谱与脐血不同，长链多不饱和 FA 水平较低，单不饱和 FA 水平较高。
本研究采用全血微分析方法，探索性地证实了长链多不饱和 FA 水平从母体向脐血和婴儿血液逐渐增加。
