May Jason Glenn, Shah Priyanka, Lemonnier Lori, Bhatti Gaurav, Koscica Jovana, Coticchia James M
Division of Pediatric Otolaryngology, Department of Otolaryngology, Wayne State University, Detroit, Michigan, USA.
Ann Otol Rhinol Laryngol. 2011 Feb;120(2):116-22. doi: 10.1177/000348941112000208.
We performed a systematic review of published literature correlating findings on endoscopic evaluation of the larynx and trachea in the pediatric population with the incidence of gastroesophageal reflux disease.
Eight articles were identified through a structured PubMed search of English-language literature using the key terms laryngopharyngeal reflux, extraesophageal reflux, and gastroesophageal reflux. A systematic review was performed relating the presence of reflux in the pediatric population to findings on endoscopic airway evaluation. A covariant analysis was performed, and each study was weighted according to the number of available samples in that study as a fraction of the total. Overall odds ratios and confidence intervals were computed for each endoscopic finding on the basis of the documented absence or presence of gastroesophageal reflux disease.
A correlation was seen between the endoscopic findings and the presence of reflux.
Arytenoid, postglottic, and vocal fold edema and erythema, lingual tonsil hypertrophy, laryngomalacia, and subglottic stenosis are among the endoscopic findings most frequently identified in patients with gastroesophageal reflux disease. Certain findings commonly encountered on endoscopic evaluation of the larynx and trachea in children who present with respiratory symptoms do indeed demonstrate a correlation with the presence of laryngopharyngeal reflux disease and may indicate the need for antireflux therapy.
我们对已发表的文献进行了系统综述，这些文献将儿科人群中喉和气管的内镜评估结果与胃食管反流病的发病率相关联。
通过使用关键词“喉咽反流”“食管外反流”和“胃食管反流”对英文文献进行结构化的PubMed检索，共识别出8篇文章。进行了一项系统综述，将儿科人群中反流的存在情况与气道内镜评估结果相关联。进行了协变量分析，每项研究根据该研究中可用样本数占总数的比例进行加权。根据记录的胃食管反流病的有无，计算每项内镜检查结果的总体优势比和置信区间。
内镜检查结果与反流的存在之间存在相关性。
杓状软骨、声门后区和声带水肿及红斑、舌扁桃体肥大、喉软化症和声门下狭窄是胃食管反流病患者中最常发现的内镜检查结果。在有呼吸道症状的儿童中，喉和气管内镜评估中常见的某些结果确实与喉咽反流病的存在相关，可能表明需要进行抗反流治疗。
