Scott W N, Hawkins R A, Killen E, Miller W R
Department of Surgery, Royal Infirmary, Edinburgh, Scotland.
J Steroid Biochem. 1990 Mar;35(3-4):399-402. doi: 10.1016/0022-4731(90)90246-o.
Plasma and cyst fluid were obtained from patients with palpable breast cysts and analysed for androgen conjugates and oestrone sulphate content by radioimmunoassay. Concentrations of androgen conjugates in cyst fluids varied from 15.6 to 475.5 mumols/l. These levels were much greater than those in plasma (1.3-5.2 mumols/l) and there was no association between values in cyst aspirates and plasmas obtained from the same individuals. Levels of oestrone sulphate in breast cyst fluids (1.5-744.0 nmol/l) were also generally in excess of those in plasma (2.0-59.9 nmol/l) and again no relationship was evident between concentrations in cyst fluid and the circulation. Neither was there a relationship between levels of androgen conjugate and oestrone sulphate in plasma. In contrast, a highly significant correlation (P less than 0.001) was identified between the androgen conjugate and oestrone sulphate content of cyst fluids. Levels of both androgen conjugates and oestrone sulphate were also significantly different in groups of cysts subdivided according to electrolyte classification, cysts with low Na+:K+ ratios having higher steroid concentrations than those with high Na+:K+ ratios. The biological significance of the relationship between the two conjugates in cyst fluids remains unclear but it is suggested that the accumulation of these steroids involves a common mechanism.
从可触及乳腺囊肿患者中获取血浆和囊液，通过放射免疫分析法分析雄激素结合物和硫酸雌酮含量。囊液中雄激素结合物的浓度在15.6至475.5μmol/L之间。这些水平远高于血浆中的水平（1.3 - 5.2μmol/L），并且从同一个体获取的囊液抽吸物和血浆中的值之间没有关联。乳腺囊液中硫酸雌酮的水平（1.5 - 744.0nmol/L）通常也超过血浆中的水平（2.0 - 59.9nmol/L），并且囊液浓度与循环中的浓度之间同样没有明显关系。血浆中雄激素结合物和硫酸雌酮的水平之间也没有关系。相比之下，囊液中雄激素结合物和硫酸雌酮含量之间存在高度显著的相关性（P小于0.001）。根据电解质分类细分的囊肿组中，雄激素结合物和硫酸雌酮的水平也存在显著差异，Na⁺:K⁺比值低的囊肿比Na⁺:K⁺比值高的囊肿具有更高的类固醇浓度。囊液中两种结合物之间关系的生物学意义仍不清楚，但有人认为这些类固醇的积累涉及一种共同机制。
