Joos K M, Blair W F, Brown T D, Gable R H
Department of Orthopaedic Surgery, University of Iowa, Iowa City.
Microsurgery. 1990;11(1):12-8. doi: 10.1002/micr.1920110105.
This study measured the hemodynamics of peripheral arterial sites in the rat, using 20 MHz pulsed ultrasonic Doppler velocimeter (PUDVM) methods. The lower extremities of 14 male Sprague-Dawley rats were studied. The targeted sites included the abdominal aorta, external iliac, proximal femoral, mid-femoral, and saphenous arteries. The hemodynamic variables of pulse period, maximum centerline velocity, lumen diameter, and mean volumetric flow were calculated interactively from temporal-spatial plots of local velocity distributions. An analysis of variance revealed significant differences between right and left sides for lumen diameter (P = 0.028) and mean volumetric flow (P less than 0.0001). The analysis showed no statistical difference for pulse period (P = 0.0836) among sites. However, three distinct groupings of sites: 1) abdominal aorta, 2) external iliac, proximal femoral, and mid-femoral arteries, and 3) saphenous artery were noted for the remaining hemodynamic variables (P less than 0.05). These results indicate that three hemodynamically distinct regions are available for microvascular research in the rat lower extremity arterial tree.
本研究采用20兆赫脉冲超声多普勒测速仪（PUDVM）方法测量了大鼠外周动脉部位的血流动力学。研究了14只雄性斯普拉格-道利大鼠的下肢。目标部位包括腹主动脉、髂外动脉、股动脉近端、股动脉中段和隐动脉。根据局部速度分布的时空图交互式计算脉搏周期、最大中心线速度、管腔直径和平均容积流量等血流动力学变量。方差分析显示，管腔直径（P = 0.028）和平均容积流量（P < 0.0001）在左右两侧之间存在显著差异。分析表明，各部位之间的脉搏周期（P = 0.0836）无统计学差异。然而，对于其余血流动力学变量，观察到三个不同的部位分组：1）腹主动脉，2）髂外动脉、股动脉近端和股动脉中段，以及3）隐动脉（P < 0.05）。这些结果表明，在大鼠下肢动脉树中有三个血流动力学不同的区域可用于微血管研究。
