通过炔二醇的氧化环缩酮化合成 aldingenin B 的三环核心。
Synthesis of the tricyclic core of aldingenin B by oxidative cyclo-ketalization of an alkyne-diol.
机构信息
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.
出版信息
Org Lett. 2011 Apr 15;13(8):2065-7. doi: 10.1021/ol200421s. Epub 2011 Mar 10.
PMID:21391664
Abstract
The preparation and selenium-mediated cyclo-ketalization of an alkyne-diol is described as a model study for the synthesis of aldingenin B. The oxidative cyclization is a simplifying transformation for aldingenin B, as it provides a convenient method for generating the tricylic core of the natural product from a functionalized cyclohexane.
摘要
描述了炔二醇的制备和硒介导的环缩酮化反应，作为合成 aldingenin B 的模型研究。该氧化环化是 aldingenin B 的一种简化转化，因为它提供了一种从功能化环己烷生成天然产物三环核心的方便方法。
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