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亚马逊利什曼原虫的比较基因组学和系统发育基因组学

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite.

作者信息

Tschoeke Diogo A, Nunes Gisele L, Jardim Rodrigo, Lima Joana, Dumaresq Aline Sr, Gomes Monete R, de Mattos Pereira Leandro, Loureiro Daniel R, Stoco Patricia H, de Matos Guedes Herbert Leonel, de Miranda Antonio Basilio, Ruiz Jeronimo, Pitaluga André, Silva Floriano P, Probst Christian M, Dickens Nicholas J, Mottram Jeremy C, Grisard Edmundo C, Dávila Alberto Mr

机构信息

Pólo de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz (Fiocruz/IOC), Rio de Janeiro, RJ, Brazil. ; Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

出版信息

Evol Bioinform Online. 2014 Sep 23;10:131-53. doi: 10.4137/EBO.S13759. eCollection 2014.

DOI:10.4137/EBO.S13759
PMID:
25336895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4182287/
Abstract

Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the "Mexicana complex", reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.

摘要

利什曼病是一种由利什曼原虫属引起的传染病。亚马逊利什曼原虫是新世界利什曼原虫属，属于墨西哥利什曼原虫复合体，能够引发所有类型的利什曼病感染。对亚马逊利什曼原虫参考菌株MHOM/BR/1973/M2269进行了测序，确定了8802个编码序列（CDS），其中大多数具有假设功能。使用六种利什曼原虫进行的比较分析显示，共有7016个直系同源基因的核心集。亚马逊利什曼原虫和墨西哥利什曼原虫拥有数量最多的独特直系同源基因，而巴西利什曼原虫的旁系同源基因数量最多。此外，系统基因组学分析证实了亚马逊利什曼原虫在“墨西哥利什曼原虫复合体”中的分类地位，加深了对新旧世界利什曼原虫分化的理解。在亚马逊利什曼原虫和智人之间鉴定出了潜在的非同源同功能酶（NISE），可为新药开发提供新的靶点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/e48e214fc92d/ebo-10-2014-131f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/68010c140320/ebo-10-2014-131f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/1415c1fc31ba/ebo-10-2014-131f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/1bf77276c0e6/ebo-10-2014-131f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/1c9b2b46a594/ebo-10-2014-131f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/bc6990d5e001/ebo-10-2014-131f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedd/4182287/1d9742d3e2a6/ebo-10-2014-131f10.jpg
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