Department of Dermatology, The General Infirmary at Leeds, Leeds, UK.
Photodermatol Photoimmunol Photomed. 2011 Apr;27(2):81-4. doi: 10.1111/j.1600-0781.2011.00574.x.
Granuloma annulare (GA) is a benign, usually self-limiting disease. Lesions may be localized or generalized with a tendency for generalized disease to follow a chronic course. There is evidence to support psoralen and ultraviolet A (PUVA) in the treatment of GA, but little data on long-term benefits. The purpose of this study was to investigate the effect of PUVA in the treatment of GA, and to establish clearance and remission rates.
We carried out a retrospective study of patients with generalized GA treated with PUVA over 13 years. Data were collected from case notes and a phototherapy database. On completion of treatment, outcome was assessed as clear, good improvement, moderate improvement and poor outcome. Follow-up data were obtained for patients who had cleared using a postal questionnaire in addition to clinic notes.
Fifty per cent of courses resulted in clearance of disease, 16% in good improvement, 25% had moderate benefit and 9% had a poor outcome. Of the patients that cleared, 79% remained in remission at 6 months but only 32% were still clear 12 months following treatment.
Our findings show clearance or good improvement of generalized GA in 66% of cases. Prolonged remission, however, occurred in less than a third of patients.
环状肉芽肿（GA）是一种良性、通常自限性疾病。病变可能局限或广泛，广泛疾病倾向于慢性过程。有证据支持补骨脂素和长波紫外线（PUVA）治疗 GA，但长期疗效的数据较少。本研究旨在探讨 PUVA 治疗 GA 的效果，并确定清除率和缓解率。
我们对 13 年来接受 PUVA 治疗的广泛 GA 患者进行了回顾性研究。数据来自病历和光疗数据库。治疗完成后，根据病情是否完全清除、明显改善、中度改善和改善不佳来评估疗效。通过在门诊病历之外，使用邮寄问卷的方式获取已清除患者的随访数据。
50%的疗程使疾病完全清除，16%的疗程有良好改善，25%的疗程有中度疗效，9%的疗程效果不佳。在病情完全清除的患者中，79%在 6 个月时仍处于缓解状态，但治疗 12 个月后仅有 32%仍处于完全清除状态。
我们的研究结果显示，66%的广泛 GA 患者得到清除或良好改善。然而，不到三分之一的患者出现持续缓解。
