芳香酶抑制剂对认知功能有不良影响吗？
Do aromatase inhibitors have adverse effects on cognitive function?
机构信息
Division of Cancer Medicine, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria, 3002, Australia.
出版信息
Breast Cancer Res. 2011 Feb 23;13(1):203. doi: 10.1186/bcr2806.
Abstract
Aromatase inhibitors are an important component of treatment for most postmenopausal women with hormone receptor-positive, early-stage breast cancer. Women taking aromatase inhibitors experience very low levels of circulating estrogen. This might be expected to result in cognitive dysfunction given the important relationship between estrogen and cognition in the basic science literature. Several studies have examined the cognitive effects of aromatase inhibitors, including two within large randomized trials which were adequately powered to detect moderate (but not small) effects. With this caveat, the available data do not support the hypothesis that aromatase inhibitors adversely affect cognitive function or that aromatase inhibitors might have a more adverse effect on cognitive function in comparison with tamoxifen. Further research is needed for confirmation.
摘要
芳香酶抑制剂是治疗大多数激素受体阳性、早期乳腺癌绝经后妇女的重要组成部分。服用芳香酶抑制剂的妇女体内循环雌激素水平非常低。考虑到基础科学文献中雌激素与认知之间的重要关系，这可能会导致认知功能障碍。一些研究已经检查了芳香酶抑制剂的认知影响，包括两项在大型随机试验中进行的研究，这些研究有足够的能力来检测中度（但不是小）的影响。有了这个警告，现有数据不支持芳香酶抑制剂会对认知功能产生不利影响的假设，也不支持芳香酶抑制剂与他莫昔芬相比可能对认知功能有更不利影响的假设。需要进一步的研究来证实。
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