Centre de Recherche Public de la Sante/Laboratoire National de Sante, Luxembourg, Grand-Duchy of Luxembourg.
Emerg Infect Dis. 2011 Mar;17(3):403-11. doi: 10.3201/eid1703.100851.
Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses--pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007-08 seasonal subtype H1N1--in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.
职业性接触猪源的人群发生与猪流感病毒（SIV）相关的血清学研究已见于美洲地区，但尚未见于欧洲。我们对 211 名有猪接触史的人群和 224 名配对对照者进行了 3 种流感病毒（大流行（H1N1）2009 年病毒、类似于禽类的内源性 H1N1 SIV 和 2007-08 年季节性 H1N1 病毒）的中和抗体水平进行了比较。与对照组相比，职业性接触猪源的人群对 SIV 和大流行（H1N1）2009 病毒的中和抗体水平更高。对照组也存在针对这些病毒的抗体，尽管其不太可能接触到这些病毒。SIV 和大流行（H1N1）2009 病毒的抗体之间存在相关性，但与季节性 H1N1 病毒的抗体无相关性。季节性流感（H1N1）病毒的连续变异可能增加了与抗原性不同的病毒发生血清学交叉反应的机会。需要进一步研究来确定血清学反应与感染之间的相关性程度。
