• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

恶性疟原虫多药耐药基因型，缅甸。

Multidrug-resistant genotypes of Plasmodium falciparum, Myanmar.

机构信息

Kunming Medical University, Yunnan, People's Republic of China.

出版信息

Emerg Infect Dis. 2011 Mar;17(3):498-501. doi: 10.3201/eid1703.100870.

DOI:10.3201/eid1703.100870
PMID:21392443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3166001/
Abstract

We performed a molecular epidemiologic survey of mutations associated with drug-resistance genes in Plasmodium falciparum in northeastern Myanmar. In this region, 3 highly mutated drug-resistance haplotypes and 1 associated with decreased quinine susceptibility were prevalent, which suggests that parasites may be resistant to multiple commonly used antimalarial drugs.

摘要

我们对缅甸东北部与耐药基因相关的疟原虫突变进行了分子流行病学调查。在该地区，有 3 种高度突变的耐药单倍型和 1 种与降低奎宁敏感性相关的单倍型流行，这表明寄生虫可能对多种常用抗疟药物具有耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/3166001/9648de5f0621/10-0870-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/3166001/b65888cecc2d/10-0870-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/3166001/9648de5f0621/10-0870-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/3166001/b65888cecc2d/10-0870-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db49/3166001/9648de5f0621/10-0870-F2.jpg

相似文献

1
Multidrug-resistant genotypes of Plasmodium falciparum, Myanmar.恶性疟原虫多药耐药基因型，缅甸。
Emerg Infect Dis. 2011 Mar;17(3):498-501. doi: 10.3201/eid1703.100870.
2
Longitudinal surveillance of drug resistance in Plasmodium falciparum isolates from the China-Myanmar border reveals persistent circulation of multidrug resistant parasites.中缅边境地区疟原虫分离株耐药性的纵向监测显示多药耐药寄生虫持续循环。
Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):320-328. doi: 10.1016/j.ijpddr.2018.05.003. Epub 2018 May 22.
3
Molecular Surveillance and in vitro Drug Sensitivity Study of Isolates from the China-Myanmar Border.中缅边境分离株的分子监测和体外药敏研究。
Am J Trop Med Hyg. 2020 Sep;103(3):1100-1106. doi: 10.4269/ajtmh.20-0235.
4
Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia.全国性调查显示，柬埔寨恶性疟原虫多位点耐药基因型的流行率非常高。
Antimicrob Agents Chemother. 2005 Aug;49(8):3147-52. doi: 10.1128/AAC.49.8.3147-3152.2005.
5
Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate.监测来自泰缅边境地区恶性疟原虫分离株对氯喹、奎宁、甲氟喹和青蒿琥酯的体外敏感性和耐药性分子标志物。
Acta Trop. 2010 Feb;113(2):190-4. doi: 10.1016/j.actatropica.2009.10.016. Epub 2009 Oct 30.
6
In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.泰国不同疟疾流行地区恶性疟原虫的体外阿托伐醌/氯胍敏感性及细胞色素b基因特征
Malar J. 2008 Jan 28;7:23. doi: 10.1186/1475-2875-7-23.
7
Significant Divergence in Sensitivity to Antimalarial Drugs between Neighboring Plasmodium falciparum Populations along the Eastern Border of Myanmar.缅甸东部边境相邻恶性疟原虫种群对抗疟药物敏感性存在显著差异。
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01689-16. Print 2017 Feb.
8
Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand-Myanmar Border.泰国-缅甸边境耐青蒿素恶性疟原虫K13突变等位基因
Emerg Infect Dis. 2016 Aug;22(8):1503-5. doi: 10.3201/eid2208.160004.
9
pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in Venezuela.委内瑞拉恶性疟原虫 pfmdr1 扩增与 pfcrt 氯喹耐药等位基因固定。
Antimicrob Agents Chemother. 2010 Apr;54(4):1572-9. doi: 10.1128/AAC.01243-09. Epub 2010 Feb 9.
10
Local emergence in Amazonia of C580Y mutants associated with artemisinin resistance.在亚马逊地区出现与青蒿素耐药性相关的 C580Y 突变体。
Elife. 2020 May 12;9:e51015. doi: 10.7554/eLife.51015.

引用本文的文献

1
Different In Vitro Drug Susceptibility Profile of Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for Drug Resistance.缅甸东北部两个相邻地区分离株的不同体外药敏谱及耐药分子标志物
Trop Med Infect Dis. 2022 Dec 17;7(12):442. doi: 10.3390/tropicalmed7120442.
2
Molecular Profiles of Multiple Antimalarial Drug Resistance Markers in and in the Mandalay Region, Myanmar.缅甸曼德勒地区恶性疟原虫多重抗疟药物耐药标志物的分子特征
Microorganisms. 2022 Oct 13;10(10):2021. doi: 10.3390/microorganisms10102021.
3
Molecular characterization of Plasmodium falciparum antifolate resistance markers in Thailand between 2008 and 2016.

本文引用的文献

1
In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.中缅边境地区恶性疟原虫临床分离株的体外敏感性与钠/氢交换体多态性的关系
Antimicrob Agents Chemother. 2010 Oct;54(10):4306-13. doi: 10.1128/AAC.00321-10. Epub 2010 Jul 19.
2
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.肯尼亚分离疟原虫株中奎宁和其他抗疟药物的体外活性与 pfnep 多态性。
Antimicrob Agents Chemother. 2010 Aug;54(8):3302-7. doi: 10.1128/AAC.00325-10. Epub 2010 Jun 1.
3
2008 年至 2016 年间泰国地区恶性疟原虫抗叶酸耐药相关标记物的分子特征
Malar J. 2020 Mar 4;19(1):107. doi: 10.1186/s12936-020-03176-x.
4
Genetic Variations Associated with Drug Resistance Markers in Asymptomatic Infections in Myanmar.与缅甸无症状感染中耐药标志物相关的遗传变异。
Genes (Basel). 2019 Sep 9;10(9):692. doi: 10.3390/genes10090692.
5
Asymptomatic malaria infections and Pfmdr1 mutations in an endemic area of Nigeria.尼日利亚流行地区无症状疟疾感染与 Pfmdr1 突变。
Malar J. 2019 Jun 27;18(1):218. doi: 10.1186/s12936-019-2833-8.
6
Longitudinal surveillance of drug resistance in Plasmodium falciparum isolates from the China-Myanmar border reveals persistent circulation of multidrug resistant parasites.中缅边境地区疟原虫分离株耐药性的纵向监测显示多药耐药寄生虫持续循环。
Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):320-328. doi: 10.1016/j.ijpddr.2018.05.003. Epub 2018 May 22.
7
Significant Divergence in Sensitivity to Antimalarial Drugs between Neighboring Plasmodium falciparum Populations along the Eastern Border of Myanmar.缅甸东部边境相邻恶性疟原虫种群对抗疟药物敏感性存在显著差异。
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01689-16. Print 2017 Feb.
8
Detection of chloroquine and artemisinin resistance molecular markers in Plasmodium falciparum: A hospital based study.恶性疟原虫中氯喹和青蒿素抗性分子标志物的检测：一项基于医院的研究。
Trop Parasitol. 2016 Jan-Jun;6(1):69-77. doi: 10.4103/2229-5070.175110.
9
Artemisinin resistance at the China-Myanmar border and association with mutations in the K13 propeller gene.中缅边境的青蒿素耐药性及其与K13螺旋桨基因变异的关联。
Antimicrob Agents Chemother. 2015 Nov;59(11):6952-9. doi: 10.1128/AAC.01255-15. Epub 2015 Aug 31.
10
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network.抗疟药物耐药性：文献综述及ICEMR网络的活动与发现
Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):57-68. doi: 10.4269/ajtmh.15-0007. Epub 2015 Aug 10.
Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.
恶性疟原虫 Na+/H+ 交换蛋白（Pfnhe-1）基因微卫星变异与体外奎宁敏感性降低的关联：来自非洲临床分离株的缺乏证实。
Am J Trop Med Hyg. 2010 May;82(5):782-7. doi: 10.4269/ajtmh.2010.09-0327.
4
Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine.恶性疟原虫的钠/氢交换体1转运蛋白与对奎宁的敏感性降低有关。
Antimicrob Agents Chemother. 2009 May;53(5):1926-30. doi: 10.1128/AAC.01243-08. Epub 2009 Mar 9.
5
Evidence of artemisinin-resistant malaria in western Cambodia.柬埔寨西部出现青蒿素耐药性疟疾的证据。
N Engl J Med. 2008 Dec 11;359(24):2619-20. doi: 10.1056/NEJMc0805011. Epub 2008 Dec 8.
6
Molecular analysis of chloroquine resistance in Plasmodium falciparum in Yunnan Province, China.中国云南省恶性疟原虫氯喹耐药性的分子分析
Trop Med Int Health. 2007 Sep;12(9):1051-60. doi: 10.1111/j.1365-3156.2007.01882.x.
7
Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites.东南亚疟原虫中选定的及假定为中性的单核苷酸多态性的地理分布。
Mol Biol Evol. 2005 Dec;22(12):2362-74. doi: 10.1093/molbev/msi235. Epub 2005 Aug 10.
8
Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia.全国性调查显示，柬埔寨恶性疟原虫多位点耐药基因型的流行率非常高。
Antimicrob Agents Chemother. 2005 Aug;49(8):3147-52. doi: 10.1128/AAC.49.8.3147-3152.2005.
9
Mekong malaria. II. Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia.湄公河疟疾。二。东南亚湄公河地区疟疾、多重耐药性与经济发展的最新情况
Southeast Asian J Trop Med Public Health. 2003;34 Suppl 4:1-102.
10
Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar.氯喹、周效磺胺/乙胺嘧啶、甲氟喹及甲氟喹-青蒿琥酯治疗缅甸北部克钦邦恶性疟的比较
Trop Med Int Health. 2004 Nov;9(11):1184-90. doi: 10.1111/j.1365-3156.2004.01323.x.