Department of Pediatrics, University Federico II, Naples, Italy.
J Pediatr. 2011 Jul;159(1):50-6. doi: 10.1016/j.jpeds.2011.01.033. Epub 2011 Mar 10.
To evaluate the efficacy of triple eradication therapy versus symptomatic therapy in children with Helicobacter pylori-associated chronic active gastritis (H pylori-ACAG).
Symptomatic patients with H pylori-ACAG (n=31) were randomly assigned into two groups: (1) patients infected with H pylori who were treated with triple eradication therapy (n = 16); and (2) patients infected with H pylori who were treated with symptomatic therapy (n=15).
After 1 year of follow-up, macroscopic appearance was significantly different in group B (P=.023), and chronic inflammation, H Pylori density, and activity were significantly higher in group B than in group A (P=.022, .007, and .002, respectively); however, we did not find a significant difference in the symptoms comparing both groups (P=.287). After 1 year of follow-up, we observed the persistence of the H pylori infection in all children who had not received eradication treatment.
There is no correlation between eradication of H pylori infection and improvement of dyspeptic symptoms. Self-eradication does not occur within 1 year of follow-up. A trend toward a higher rate of chronic inflammation in noneradicated children at 1 year limited the time of our study.
评估三联根除疗法与对症治疗在儿童幽门螺杆菌相关性慢性活动性胃炎（H pylori-ACAG）中的疗效。
将 H pylori-ACAG 的有症状患者（n=31）随机分为两组：（1）接受三联根除疗法治疗的 H pylori 感染患者（n=16）；和（2）接受对症治疗的 H pylori 感染患者（n=15）。
在 1 年的随访后，B 组的宏观表现明显不同（P=.023），B 组的慢性炎症、幽门螺杆菌密度和活性均明显高于 A 组（P=.022、P=.007 和 P=.002）；然而，两组间的症状比较并无显著差异（P=.287）。在 1 年的随访后，我们观察到所有未接受根除治疗的儿童均存在幽门螺杆菌感染的持续存在。
幽门螺杆菌感染的根除与消化不良症状的改善之间没有相关性。在 1 年的随访中，自行根除不会发生。未根除儿童在 1 年内慢性炎症发生率较高的趋势限制了我们研究的时间。
