Animal Reproduction Division, Indian Veterinary Research Institute, Izatnagar 243122, India.
Anim Reprod Sci. 2011 Mar;124(1-2):61-4. doi: 10.1016/j.anireprosci.2011.02.020. Epub 2011 Feb 18.
The objective of this study was to examine the follicular fluid biochemical and hormonal changes associated with ovarian follicular cysts in buffalo. Follicular fluid was aspirated from eight cysts and eight preovulatory follicles, and subjected to biochemical and hormonal analyses. Cysts were characterized by a greater (P<0.01) concentration of nitric oxide and lesser concentrations of ascorbic acid and glucose than that of preovulatory follicles (P<0.01 and P<0.05, respectively). Furthermore, follicular cysts had greater concentrations of progesterone (P<0.001), triiodothyronine (T(3)) and cortisol (P<0.05) and lesser concentrations of insulin (P<0.001) than preovulatory follicles. The results indicate follicular cysts in buffalo have an altered biochemical and hormonal composition. The alterations include increases in nitric oxide, progesterone, cortisol and T(3) concentrations with a concurrent reduction in ascorbic acid, insulin and glucose concentrations. The study suggests that greater progesterone concentrations possibly inhibit the onset of LH surge resulting in formation of follicular cysts in buffalo. In addition, it implies the plausible role of intra-ovarian regulators such as nitric oxide, ascorbic acid and insulin in development of the condition.
本研究旨在探讨水牛卵巢滤泡囊肿相关的滤泡液生化和激素变化。从 8 个囊肿和 8 个排卵前滤泡中抽吸滤泡液，并进行生化和激素分析。囊肿的特点是一氧化氮浓度较高（P<0.01），抗坏血酸和葡萄糖浓度较低（分别为 P<0.01 和 P<0.05）。此外，滤泡囊肿的孕酮（P<0.001）、三碘甲状腺原氨酸（T（3））和皮质醇（P<0.05）浓度较高，而胰岛素浓度较低（P<0.001）。结果表明，水牛滤泡囊肿的生化和激素组成发生了改变。这些改变包括一氧化氮、孕酮、皮质醇和 T（3）浓度的增加，同时抗坏血酸、胰岛素和葡萄糖浓度的降低。该研究表明，孕酮浓度的增加可能抑制 LH 峰的出现，导致水牛滤泡囊肿的形成。此外，这暗示了一氧化氮、抗坏血酸和胰岛素等卵巢内调节剂在该疾病发展中的可能作用。
