脂肪组织干细胞。
Stem cells from adipose tissue.
机构信息
Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego 5, 02-004, Warsaw, Poland.
出版信息
Cell Mol Biol Lett. 2011 Jun;16(2):236-57. doi: 10.2478/s11658-011-0005-0. Epub 2011 Mar 9.
Abstract
This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.
摘要
这是一篇关于从脂肪组织中分离的基质细胞的发育可塑性和治疗潜力的日益增长的科学兴趣的综述。脂肪来源的干细胞/基质细胞（ASCs）是丰富存在于脂肪组织中的多能体干细胞。已经表明，ASCs 可以分化为几种谱系，包括脂肪细胞、软骨细胞、成骨细胞、神经元细胞、内皮细胞和心肌细胞。同时，脂肪组织可以通过微创程序采集，这使其成为成人干细胞的有前途的来源。因此，人们相信 ASCs 可能成为目前可用的成人干细胞（例如骨髓基质细胞）的替代物，用于再生医学的潜在应用。在这篇综述中，我们介绍了脂肪来源的干细胞领域的基本信息及其在各种应用中的潜在用途。
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本文引用的文献
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Acta Neurochir (Wien). 2010 Oct;152(10):1771-7. doi: 10.1007/s00701-010-0698-2. Epub 2010 Jun 24.
2
Human adipose derived stromal cells heal critical size mouse calvarial defects.人脂肪来源的基质细胞可修复小鼠临界大小颅骨缺损。
PLoS One. 2010 Jun 17;5(6):e11177. doi: 10.1371/journal.pone.0011177.
3
Soluble factors from ASCs effectively direct control of chondrogenic fate.脂肪间充质干细胞分泌的可溶性因子能有效地定向控制软骨形成命运。
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Unsorted human adipose tissue-derived stem cells promote angiogenesis and myogenesis in murine ischemic hindlimb model.未分类的人脂肪组织来源的干细胞促进鼠缺血后肢模型中的血管生成和肌生成。
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