National Institute for Agro-Environmental Sciences, Tsukuba, Ibaraki, Japan.
Pest Manag Sci. 2011 Apr;67(4):474-82. doi: 10.1002/ps.2092. Epub 2011 Jan 11.
Recently in Japan, isolates resistant to boscalid, a succinate dehydrogenase inhibitor (SDHI), have been detected in Corynespora cassiicola (Burk. & Curt.) Wei and Podosphaera xanthii (Castaggne) Braun & Shishkoff, the pathogens causing Corynespora leaf spot and powdery mildew disease on cucumber, respectively. Resistant isolates of C. cassiicola are widely distributed and represent a serious problem in disease control at present. Novel SDHI fungicides, including fluopyram, are now under development.
The growth of very highly boscalid-resistant, highly resistant and sensitive isolates of C. cassiicola was strongly suppressed on fluopyram-amended YBA agar medium. Although boscalid and another SDHI, penthiopyrad, hardly controlled Corynespora leaf spot and powdery mildew on cucumber plants when very highly or highly boscalid-resistant isolates were employed for inoculation, fluopyram still exhibited excellent control efficacy against these resistant isolates as well as sensitive isolates of C. cassiicola and P. xanthii.
Differential sensitivity to boscalid, penthiopyrad and fluopyram, clearly found in these two important pathogens of cucumber, may indicate involvement of a slightly distinct site of action for fluopyram from the two other SDHIs. This finding may lead to the discovery of unique SDHIs in the future.
最近在日本，分别导致黄瓜上的尾孢叶斑病和白粉病的病原菌辣椒尾孢菌和瓜白粉病菌中检测到对琥珀酸脱氢酶抑制剂（SDHI）波尔多液产生抗性的分离株。辣椒尾孢菌的抗性分离株广泛分布，目前是病害防治的一个严重问题。目前正在开发包括氟吡菌酰胺在内的新型 SDHI 杀菌剂。
在添加氟吡菌酰胺的 YBA 琼脂培养基上，非常高度对波尔多液具有抗性、高度对波尔多液具有抗性和敏感的辣椒尾孢菌分离株的生长受到强烈抑制。虽然波尔多液和另一种 SDHI 戊唑醇几乎不能控制当使用非常高度或高度对波尔多液具有抗性的分离株进行接种时黄瓜植株上的尾孢叶斑病和白粉病，但氟吡菌酰胺对这些抗性分离株以及辣椒尾孢菌和瓜白粉病菌的敏感分离株仍表现出优异的防治效果。
在这两种重要的黄瓜病原菌中明显发现对波尔多液、戊唑醇和氟吡菌酰胺的敏感性差异，可能表明氟吡菌酰胺的作用靶位与其他两种 SDHI 略有不同。这一发现可能导致未来发现独特的 SDHI。
