Sukhanov D S, Ivanov A K, Romantsev M G, Kovalenko A L, Demidik S N, Kuchko I V
Klin Med (Mosk). 2010;88(6):14-9.
Modem immunopathogenetic concepts of tuberculosis infection are summarized. Th1-mediated immune response is shown to play a leading role in the formation of antituberculosis immunity. Cytokine balance (especially that of interferon-y) has marked influence on the outcome of infection. The data on efficiency of modern immunotropic drugs suggest advantages of interferon inductors, in the first place cyclopheron, for pathogenetic therapy. Cyclopheron participates in regulation of endogenous interferon-gamma production and thereby in activation of TH1-mediated immune response that accelerates abacillation, closes cavities in organs undergoing degeneration, and improves the X-ray picture. A succinate-containing cyclopheron solution was shown to positively change the cytokine profile and X-ray structure of respiratory organs in patients with tuberculosis.
总结了结核病感染的现代免疫病理发生学概念。研究表明，Th1介导的免疫反应在抗结核免疫的形成中起主导作用。细胞因子平衡（尤其是干扰素-γ的平衡）对感染结果有显著影响。关于现代免疫调节药物疗效的数据表明，干扰素诱导剂，首先是环磷酰胺，在病因治疗方面具有优势。环磷酰胺参与内源性干扰素-γ产生的调节，从而激活Th1介导的免疫反应，加速脱痂，闭合发生变性的器官中的空洞，并改善X线影像。含琥珀酸盐的环磷酰胺溶液被证明可使结核病患者呼吸器官的细胞因子谱和X线结构发生积极变化。
