Suhanov D S
Ter Arkh. 2013;85(3):110-7.
The review summarizes current views on the immunopathogenesis of tuberculosis infection. It shows the leading role of a Th1 cytokine response in the formation of antituberculosis protective immunity and the impact of cytokine balance on disease outcomes. Data on the efficacy of current groups of immunomodulators used in the therapy of tuberculosis (immunomodulators, peptides, cytokine preparations, and synthetic immunomodulators of different chemical structures) are considered. Particular emphasis is placed on a group of interferon inducers as drugs for pathogenetic therapy, of which cycloferon is most important. The data of studies of the effect of cycloferon on the elaboration of interferon-gamma that is able to activate a Th1 immune response, which promotes the shorter time of abacillation and decay cavity closure and positive X-ray changes, are given.
本综述总结了当前关于结核感染免疫发病机制的观点。它显示了Th1细胞因子反应在抗结核保护性免疫形成中的主导作用以及细胞因子平衡对疾病转归的影响。文中考虑了目前用于结核病治疗的各类免疫调节剂（免疫调节剂、肽、细胞因子制剂以及不同化学结构的合成免疫调节剂）的疗效数据。特别强调了作为致病疗法药物的一组干扰素诱导剂，其中环芬肽最为重要。文中给出了环芬肽对干扰素-γ产生影响的研究数据，干扰素-γ能够激活Th1免疫反应，促进脱痂和空洞闭合时间缩短以及X线出现阳性变化。
