Ignacio V, Gansmuller A, Collins V P, Suard I, Jacque C
INSERM U 134, Hôpital de la Salpêtrière, Paris, France.
Glia. 1990;3(2):140-9. doi: 10.1002/glia.440030208.
Fragments of corpus callosum from adult rabbit have been implanted into the brain of newborn mice. Previous studies had shown that under such conditions transplant-derived astroglial cells differentiate in the host and survive for at least 2 months. The present study was devised to clarify the fate of the differentiated astrocytes present in the adult transplant by using combined ultrastructural and immunohistochemical approaches. These mature cells are shown to degenerate and die within 2 days after the implantation. Therefore, we suggest that stem cells present in adult tissue would account for the surviving population of transplant-derived glial cells.
已将成年兔的胼胝体碎片植入新生小鼠的大脑。先前的研究表明，在这种情况下，移植来源的星形胶质细胞会在宿主中分化并存活至少2个月。本研究旨在通过联合超微结构和免疫组织化学方法来阐明成年移植物中分化的星形胶质细胞的命运。结果显示，这些成熟细胞在植入后2天内就会退化并死亡。因此，我们认为成年组织中存在的干细胞是移植来源的神经胶质细胞存活群体的原因。
