缝隙连接蛋白 32 和 47 介导少突胶质细胞-星形胶质细胞和少突胶质细胞-少突胶质细胞缝隙连接耦联。
Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling.
机构信息
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104–6077, USA.
出版信息
Neurobiol Dis. 2011 Jun;42(3):506-13. doi: 10.1016/j.nbd.2011.03.003. Epub 2011 Mar 8.
Abstract
In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30. We used fluorescent dyes to examine functional coupling in acute slices from the cerebra of mice lacking Cx32 and/or Cx47. In the corpus callosum, unexpectedly, oligodendrocytes appeared to be directly and exclusively coupled to other oligodendrocytes (O:O coupling), and electron microscopy revealed gap junctions between adjacent oligodendrocytes. O:O coupling was more affected in mice lacking Cx32 than in mice lacking Cx47. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32, was required for O:A coupling.
摘要
除了星形胶质细胞之间广泛的缝隙连接偶联外，少突胶质细胞被认为仅通过由 Cx47:Cx43 和 Cx32:Cx30 组成的异型缝隙连接与星形胶质细胞偶联（O:A 偶联）。我们使用荧光染料检查了来自缺乏 Cx32 和/或 Cx47 的小鼠大脑切片中的功能偶联。令人意外的是，在胼胝体中，少突胶质细胞似乎直接且仅与其他少突胶质细胞偶联（O:O 偶联），电子显微镜显示了相邻少突胶质细胞之间的缝隙连接。缺乏 Cx32 的小鼠中 O:O 偶联受影响比缺乏 Cx47 的小鼠更严重。在大脑皮层中，少突胶质细胞似乎直接且仅与星形胶质细胞偶联；O:A 偶联需要 Cx47，但不需要 Cx32。
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