Otorhinolaryngology Research Center,Tehran University of Medical Sciences, Amir Alam Educational Hospital, Tehran, Iran.
Ann Diagn Pathol. 2011 Aug;15(4):233-6. doi: 10.1016/j.anndiagpath.2010.10.009. Epub 2011 Mar 10.
It seems apparently that the 2 separate anatomical areas (nasal cavity and paranasal sinus mucosa) are indeed one single unit with an identical behavior during inflammatory process. Similar histopathologic evidence in long-term condition could emphasize on the concept of rhinosinusitis in patients with inflammatory paranasal sinus disease. Prospective study was performed on 50 consecutive patients with polyposis in 2 different groups, one with and the other without asthma. Inferior turbine and polyp with ethmoid sinus origin were selected to compare the histopathologic findings of the surgical specimens from the 2 sites (affected sinus vs apparently unaffected nose). The general degree of inflammation, epithelial thickening, and inflammatory cell count were measured. The degree of inferior turbinate inflammation correlated with that of the ipsilateral polyp of ethmoid sinus in both groups. In addition, the total inflammatory cell count was comparable. There was no statistically significant difference in total polymorphonuclear, lymphocyte, and eosinophil count between the 2 sites in each group (P > .05). The ethmoid sinus inflammation in polypoid chronic sinusitis is accompanied by a proportionate inferior turbinate inflammation, not only in the patients with asthma but also in those with isolated sinonasal polyposis.
似乎很明显，两个独立的解剖区域（鼻腔和鼻旁窦黏膜）实际上是一个单一的单元，在炎症过程中具有相同的行为。在长期情况下类似的组织病理学证据可以强调患有炎症性鼻旁窦疾病的患者存在鼻-鼻窦炎的概念。对 50 例连续的息肉患者进行了前瞻性研究，将患者分为两组，一组有哮喘，另一组没有哮喘。选择下鼻甲和筛窦来源的息肉，比较来自两个部位（受影响的鼻窦与明显未受影响的鼻腔）的手术标本的组织病理学发现。测量炎症的总体程度、上皮增厚和炎症细胞计数。两组患者的下鼻甲炎症程度与同侧筛窦息肉的炎症程度相关。此外，总炎性细胞计数相当。两组患者的两个部位的总多形核白细胞、淋巴细胞和嗜酸性粒细胞计数均无统计学差异（P>0.05）。在伴有哮喘的患者以及单纯鼻-鼻窦炎息肉患者中，鼻旁窦炎症伴随下鼻甲炎症，在息肉性慢性鼻窦炎中是常见的。
