Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.
Pharmacol Res. 2011 Aug;64(2):113-22. doi: 10.1016/j.phrs.2011.03.001. Epub 2011 Mar 21.
The cancer preventive activities of tea (Camellia sinensis Theaceae) have been studied extensively. Inhibition of tumorigenesis by green tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancers of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, prostate, and mammary glands. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea. These molecular events can result in cellular changes, such as enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis. Nevertheless, the molecular mechanisms of inhibition of carcinogenesis in animals and humans remain to be further investigated. Future research directions in this area are discussed.
茶（山茶科）的防癌活性已被广泛研究。绿茶提取物和茶多酚已在不同的动物模型中显示出对肿瘤形成的抑制作用，包括皮肤癌、肺癌、口腔癌、食管癌、胃癌、小肠癌、结肠癌、膀胱癌、肝癌、胰腺癌和乳腺癌。许多细胞系的研究表明，（-）-表没食子儿茶素-3-没食子酸酯（EGCG）可调节信号转导和代谢途径，EGCG 是绿茶中最丰富、最活跃的多酚。这些分子事件可导致细胞变化，如增强细胞凋亡、抑制细胞增殖和抑制血管生成。然而，动物和人类抑制致癌作用的分子机制仍有待进一步研究。讨论了该领域的未来研究方向。
