Yang Chung S, Ju Jihyeung, Lu Gary, Xiao Hang, Hao Xingpei, Sang Shengmin, Lambert Joshua D
Department of Chemical Biology, Ernest Mario School of Phar-macy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.
Asia Pac J Clin Nutr. 2008;17 Suppl 1(Suppl 1):245-8.
The inhibition of tumorigenesis by tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancer of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancrease, prostate, and mammary glands. Caffeine is also active in inhibition of tumorigenesis on the skin, lung, and perhaps other organs. In spite of many in vitro and in vivo studies, the molecular mechanisms for the cancer preventive actions of these compounds are not clearly known. The relationship between tea consumption and cancer risk has not been conclusively demonstrated, and the relationship may become more clear if we consider the effects of specific types of tea, at defined doses, in populations with certain dietary patterns or genetic polymorphisms. Human intervention trials and large prospective studies are needed to further assess the cancer preventive activities of tea constituents.
茶提取物和茶多酚对肿瘤发生的抑制作用已在不同动物模型中得到证实，包括皮肤癌、肺癌、口腔癌、食管癌、胃癌、小肠癌、结肠癌、膀胱癌、肝癌、胰腺癌、前列腺癌和乳腺癌的动物模型。咖啡因对皮肤癌、肺癌以及可能对其他器官的肿瘤发生抑制也有作用。尽管进行了许多体外和体内研究，但这些化合物防癌作用的分子机制尚不清楚。饮茶与癌症风险之间的关系尚未得到确凿证明，如果我们考虑特定类型的茶在特定剂量下对具有特定饮食模式或基因多态性人群的影响，这种关系可能会更加清晰。需要进行人体干预试验和大型前瞻性研究，以进一步评估茶成分的防癌活性。
