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白藜芦醇、表没食子儿没食子酸酯和姜黄素用于癌症治疗:源于其促凋亡特性的挑战

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties.

作者信息

Chimento Adele, D'Amico Maria, De Luca Arianna, Conforti Francesca Luisa, Pezzi Vincenzo, De Amicis Francesca

机构信息

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.

Health Center, University of Calabria, 87036 Rende, Italy.

出版信息

Life (Basel). 2023 Jan 17;13(2):261. doi: 10.3390/life13020261.

DOI:10.3390/life13020261
PMID:36836619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9962739/
Abstract

Plant-derived bioactive compounds are gaining wide attention for their multiple health-promoting activities and in particular for their anti-cancer properties. Several studies have highlighted how they can prevent cancer initiation and progression, improve the effectiveness of chemotherapy, and, in some cases, limit some of the side effects of chemotherapy agents. In this paper, we provide an update of the literature on the anti-cancer effects of three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, and curcumin, with a special focus on the anti-cancer molecular mechanisms inducing apoptosis in the major types of cancers globally.

摘要

植物源生物活性化合物因其多种促进健康的活性,尤其是抗癌特性而受到广泛关注。多项研究强调了它们如何能够预防癌症的发生和发展、提高化疗的有效性,并且在某些情况下,限制化疗药物的一些副作用。在本文中,我们提供了关于三种经过广泛研究的植物源化合物(即白藜芦醇、表没食子儿没食子酸酯和姜黄素)抗癌作用的文献综述,特别关注在全球主要癌症类型中诱导细胞凋亡的抗癌分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/36bb053325e5/life-13-00261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/4c3290725050/life-13-00261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/9ef93d60a0b0/life-13-00261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/36bb053325e5/life-13-00261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/4c3290725050/life-13-00261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/9ef93d60a0b0/life-13-00261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735a/9962739/36bb053325e5/life-13-00261-g002.jpg

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Green Tea Catechins: Nature's Way of Preventing and Treating Cancer.绿茶儿茶素:预防和治疗癌症的自然之道。
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Drug Des Devel Ther. 2025 Jan 11;19:201-218. doi: 10.2147/DDDT.S483404. eCollection 2025.
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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy.PD-1/PD-L1信号轴在肿瘤发生中的作用及其被生物活性天然化合物靶向用于癌症免疫治疗的研究
Mil Med Res. 2024 Dec 18;11(1):82. doi: 10.1186/s40779-024-00586-9.
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Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.药用蘑菇提取物的蛋白质组学研究揭示了在晚期结肠癌动物模型中通过核糖体生物发生、翻译和代谢途径的抗肿瘤机制。
Front Pharmacol. 2024 Oct 18;15:1475102. doi: 10.3389/fphar.2024.1475102. eCollection 2024.
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