Department of Chemical Biology, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854-8020, USA.
Nutr Cancer. 2010;62(7):931-7. doi: 10.1080/01635581.2010.509536.
Extracts of green tea and green tea polyphenols have exhibited inhibitory effects against the formation and development of tumors at different organ sites in animals. These include animal models for skin, lung, oral cavity, esophagus, stomach, intestine, colon, liver, pancreas, bladder, mammary gland, and prostate cancers. In addition to suppressing cell proliferation, promoting apoptosis, and modulating signaling transduction, green tea polyphenols, especially (-)-epigallocatechin-3-gallate, also inhibit cell invasion, angiogenesis, and metastasis. This article reviews data on the cancer preventive activities of green tea polyphenols, possible mechanisms involved, and the relationship between green tea consumption and human cancer risk.
绿茶和绿茶多酚提取物在不同器官的动物肿瘤形成和发展中表现出抑制作用。这些包括皮肤、肺、口腔、食道、胃、肠、结肠、肝、胰腺、膀胱、乳腺和前列腺癌的动物模型。除了抑制细胞增殖、促进细胞凋亡和调节信号转导外，绿茶多酚，特别是（-）-表没食子儿茶素-3-没食子酸酯，还抑制细胞侵袭、血管生成和转移。本文综述了绿茶多酚的抗癌活性、可能涉及的机制以及绿茶消费与人类癌症风险之间的关系。
