Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, University of Helsinki, FIN-00029 Helsinki, Finland.
Best Pract Res Clin Endocrinol Metab. 2011 Apr;25(2):287-302. doi: 10.1016/j.beem.2010.09.007.
The testis has been shown to be highly susceptible to the toxic effects of cancer therapy at all stages of life. Young cancer survivors are approximately half as likely as their siblings to sire a pregnancy. Radiation therapy to the testes and high cumulative dose of alkylating agents are the major factors decreasing the probability of fertility. This review aims to present an overview of the current state of knowledge in mechanisms how human spermatogonia proliferate and differentiate and how cancer therapy affects germ cells, what are the options for fertility preservation and what are the clinical risks and limitations related to such procedures. This area of research is discussed in the context of the potential future options that may become available for preserving fertility in male cancer patients.
睾丸在生命的各个阶段都极易受到癌症治疗的毒性影响。年轻的癌症幸存者与他们的兄弟姐妹相比，生育的可能性大约低一半。睾丸的放射治疗和高累积剂量的烷化剂是降低生育能力的主要因素。本综述旨在概述目前对人类精原细胞增殖和分化的机制的了解，以及癌症治疗如何影响生殖细胞，有哪些保留生育能力的选择，以及与这些程序相关的临床风险和限制。在讨论这个研究领域时，考虑了男性癌症患者可能保留生育能力的未来潜在选择。
