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婴儿体内肺炎克雷伯菌质粒编码的ACC-1 AmpC向大肠杆菌的转移以及肺炎克雷伯菌对亚胺培南不渗透性的选择

In vivo transfer of plasmid-encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an infant and selection of impermeability to imipenem in K. pneumoniae.

作者信息

Bidet Philippe, Burghoffer Béatrice, Gautier Valérie, Brahimi Naïma, Mariani-Kurkdjian Patricia, El-Ghoneimi Alaa, Bingen Edouard, Arlet Guillaume

机构信息

Service de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75395 Paris cedex 19, France.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3562-5. doi: 10.1128/AAC.49.8.3562-3565.2005.

DOI:10.1128/AAC.49.8.3562-3565.2005
PMID:16048985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196243/
Abstract

We describe in vivo selection of a Klebsiella pneumoniae strain with diminished imipenem susceptibility attributable to plasmid-encoded ACC-1 beta-lactamase production and loss of a 36-kDa major outer membrane protein, together with transfer of this plasmid from K. pneumoniae to Escherichia coli in a Tunisian infant.

摘要

我们描述了在突尼斯一名婴儿体内对一株肺炎克雷伯菌进行的体内筛选，该菌株对亚胺培南的敏感性降低，这归因于质粒编码的ACC-1β-内酰胺酶的产生以及一种36 kDa主要外膜蛋白的缺失，同时这种质粒从肺炎克雷伯菌转移到了大肠杆菌。

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本文引用的文献

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Metallo-beta-lactamases: the quiet before the storm?金属β-内酰胺酶：暴风雨前的宁静？
Clin Microbiol Rev. 2005 Apr;18(2):306-25. doi: 10.1128/CMR.18.2.306-325.2005.
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Escherichia coli producing an ACC-1 class C beta-lactamase isolated in Barcelona, Spain.在西班牙巴塞罗那分离出的产ACC-1类C型β-内酰胺酶的大肠杆菌。
Antimicrob Agents Chemother. 2005 Feb;49(2):866-7. doi: 10.1128/AAC.49.2.866-867.2005.
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Characterization of Escherichia coli O157 : H7 isolates causing haemolytic uraemic syndrome in France.法国引起溶血性尿毒综合征的大肠杆菌O157 : H7分离株的特性分析
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Factors associated with antimicrobial resistance among clinical isolates of Klebsiella pneumoniae: 1-year survey in a French university hospital.肺炎克雷伯菌临床分离株中与抗菌药物耐药性相关的因素：法国一家大学医院的1年调查
Eur J Clin Microbiol Infect Dis. 2004 Jun;23(6):456-62. doi: 10.1007/s10096-004-1144-2. Epub 2004 May 18.
5
Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital.法国一家医院中出现产超广谱β-内酰胺酶VEB-1的鲍曼不动杆菌菌株暴发。
J Clin Microbiol. 2003 Aug;41(8):3542-7. doi: 10.1128/JCM.41.8.3542-3547.2003.
6
Molecular epidemiology and characterization of plasmid-encoded beta-lactamases produced by Tunisian clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins.突尼斯肠炎沙门氏菌血清型姆班达卡临床分离株产生的质粒编码β-内酰胺酶的分子流行病学及特征分析，该分离株对广谱头孢菌素耐药。
J Clin Microbiol. 2003 Jul;41(7):2940-5. doi: 10.1128/JCM.41.7.2940-2945.2003.
7
[Identification of plasmid-encoded cephalosporinase ACC-1 among various enterobacteria (Klebsiella pneumoniae, Proteus mirabilis, Salmonella) isolated from a Tunisian hospital (Sfax 997-2000)].[从突尼斯一家医院（斯法克斯997 - 2000）分离的各种肠杆菌（肺炎克雷伯菌、奇异变形杆菌、沙门氏菌）中鉴定质粒编码的头孢菌素酶ACC - 1]
Pathol Biol (Paris). 2002 Feb;50(1):7-11. doi: 10.1016/s0369-8114(01)00260-7.
8
Plasmid-determined AmpC-type beta-lactamases.质粒介导的AmpC型β-内酰胺酶
Antimicrob Agents Chemother. 2002 Jan;46(1):1-11. doi: 10.1128/AAC.46.1.1-11.2002.
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Eur J Clin Microbiol Infect Dis. 2000 Nov;19(11):893-5. doi: 10.1007/s100960000386.
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Emergence of imipenem resistance in Klebsiella pneumoniae owing to combination of plasmid-mediated CMY-4 and permeability alteration.肺炎克雷伯菌中由于质粒介导的CMY-4与通透性改变相结合而出现亚胺培南耐药性。
J Antimicrob Chemother. 2000 Dec;46(6):895-900. doi: 10.1093/jac/46.6.895.