Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea.
Vet J. 2012 Feb;191(2):188-92. doi: 10.1016/j.tvjl.2011.02.013. Epub 2011 Mar 11.
This study investigated the use of sprayed intraperitoneal bupivacaine to relieve postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy (LOVH) in dogs. Sixteen sexually intact female dogs were randomly assigned to two groups. The sprayed intraperitoneal bupivacaine (SIB) group received 4.4 mg/kg of sprayed intraperitoneal bupivacaine diluted to 0.25% with an equivalent volume of saline after pneumoperitoneum. The control group received 1.76 mL/kg of saline in a similar fashion. Both groups received preoperative periportal 5% bupivacaine (1 mL) before incision. Postoperative pain was measured using the short form of the Glasgow composite measures pain scale (CMPS-SF, 0-24). Serum cortisol and glucose concentrations were measured preoperatively and 0.5, 1, 2, 4, 6, 12, and 24h postoperatively. The SIB group had significantly lower CMPS-SF compared to the control group 1, 2, 4, 6, and 12h after the operation. Cortisol concentrations were significantly increased from preoperative concentrations in the control group at 0.5, 1, 2, and 4h post operation and at 0.5 and 1h post operation in the SIB group. No significant differences were seen in serum glucose within each group. This report suggests that the use of sprayed intraperitoneal bupivacaine can be used as part of a multimodal approach for pain management after LOVH in dogs.
本研究旨在探讨在腹腔镜卵巢子宫切除术（LOVH）后，通过喷洒腹腔内布比卡因（SIB）缓解犬术后疼痛行为和生化应激反应。将 16 只未绝育的雌性犬随机分为两组。SIB 组在气腹后接受 4.4mg/kg 喷洒腹腔内布比卡因（0.25%，用等容量生理盐水稀释）。对照组以类似方式接受 1.76mL/kg 的生理盐水。两组均在切口前于门静脉周围注射术前 5%布比卡因（1mL）。术后疼痛采用格拉斯哥复合疼痛量表短表（CMPS-SF，0-24）进行测量。术前及术后 0.5、1、2、4、6、12 和 24 小时测量血清皮质醇和血糖浓度。SIB 组在术后 1、2、4、6 和 12 小时的 CMPS-SF 显著低于对照组。对照组在术后 0.5、1、2 和 4 小时以及 SIB 组在术后 0.5 和 1 小时的皮质醇浓度较术前显著升高。两组的血清葡萄糖均无显著差异。本报告表明，SIB 可作为犬 LOVH 后多模式疼痛管理的一部分。
