Casteilla L, Planat-Benard V, Bourin P, Laharrague P, Cousin B
UMR UPS/CNRS/EFS 5273, U103, Inserm, BP 84225, 31432 Toulouse, France.
Transfus Clin Biol. 2011 Apr;18(2):124-8. doi: 10.1016/j.tracli.2011.01.008. Epub 2011 Mar 11.
Adipose tissue is abundant and well known for its involvement in obesity and associated metabolic disorders. Its uses in regenerative medicine recently attracted many investigators, as large amounts of this tissue can be easily obtained using liposuction and it contains several populations of immature cells. The largest pool of such cells corresponds to immature stromal cells, called adipose-derived stromal cells (ADSCs). These cells are purified after proteolytic digestion of adipose tissue and selection by an adherent step. ADSCs display many common features with mesenchymal stem cells derived from bone marrow, including paracrine activity, but with some specific features, among which a greater angiogenic potential. This potential is now investigating at clinical level to treat critical ischemic hindlimb by autologous cells. Other potentials are also investigated and the treatment of fistula associated or not with Crohn's disease is reaching now phase III level.
脂肪组织丰富，因其与肥胖及相关代谢紊乱有关而广为人知。其在再生医学中的应用最近吸引了许多研究者，因为使用抽脂术可以轻松获取大量这种组织，并且它含有几类未成熟细胞。这类细胞中数量最多的是未成熟的基质细胞，称为脂肪来源的基质细胞（ADSCs）。这些细胞在对脂肪组织进行蛋白水解消化并通过贴壁步骤进行筛选后得以纯化。ADSCs与源自骨髓的间充质干细胞具有许多共同特征，包括旁分泌活性，但也有一些特定特征，其中血管生成潜力更大。目前正在临床层面研究这种潜力，以通过自体细胞治疗严重缺血性后肢。其他潜力也在研究中，与克罗恩病相关或不相关的瘘管治疗目前已进入III期。
