鲍曼不动杆菌 MDR-TJ 的基因组序列。
Genome sequence of Acinetobacter baumannii MDR-TJ.
机构信息
Department of Physics, Tianjin University, Tianjin 300072, China.
出版信息
J Bacteriol. 2011 May;193(9):2365-6. doi: 10.1128/JB.00226-11. Epub 2011 Mar 11.
Abstract
Acinetobacter baumannii is a pathogenic species of bacteria, identified as an aerobic gram-negative bacterium, that is resistant to most antibiotics. In this study, the MDR-TJ strain was isolated at the Second Hospital of Tianjin Medical University, China, and was found to be resistant to penicillin, cephalosporins, aminoglycosides, quinolones, and also imipenem. The genome sequence of Acinetobacter baumannii strain MDR-TJ was determined by using a combination of 454 pyrosequencing and paired-end sequencing performed with the Roche Genome Sequencer FLX system to generate a scaffolded assembly.
摘要
鲍曼不动杆菌是一种致病性细菌，被鉴定为需氧革兰氏阴性菌，对大多数抗生素具有耐药性。本研究在中国天津医科大学第二医院分离出一株多药耐药性鲍曼不动杆菌（MDR-TJ）株，该菌株对青霉素、头孢菌素类、氨基糖苷类、喹诺酮类和亚胺培南均具有耐药性。采用 454 焦磷酸测序和罗氏基因组测序仪 FLX 系统进行的配对末端测序相结合的方法，测定了鲍曼不动杆菌 MDR-TJ 株的基因组序列，生成了一个支架组装。
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