Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
J Agric Food Chem. 2011 Apr 27;59(8):3454-84. doi: 10.1021/jf200439q. Epub 2011 Mar 14.
Potatoes, tomatoes, and aubergines are all species of the Solanum genus and contain a vast array of secondary metabolites including calystegine alkaloids, phenolic compounds, lectins, and glycoalkaloids. Glycoalkaloids have been the subject of many literature papers, occur widely in the human diet, and are known to induce toxicity. Therefore, from a food safety perspective further information is required regarding their analysis, toxicity, and bioavailability. This is especially important in crop cultivars derived from wild species to prevent glycoalkaloid-induced toxicity. A comprehensive review of the bioactivity of glycoalkaloids and their aglycones of the Solanum species, particularly focused on comparison of their bioactivities including their anticancer, anticholesterol, antimicrobial, anti-inflammatory, antinociceptive, and antipyretic effects, toxicity, and synergism of action of the principal Solanum glycoalkaloids, correlated to differences of their individual molecular structures is presented.
土豆、西红柿和茄子均属于茄属植物，含有大量的次生代谢产物，包括喇叭茶宁生物碱、酚类化合物、凝集素和糖苷生物碱。糖苷生物碱是许多文献的主题，广泛存在于人类饮食中，已知会引起毒性。因此，从食品安全的角度来看，需要进一步了解它们的分析、毒性和生物利用度。这在源自野生种的作物品种中尤为重要，以防止糖苷生物碱引起的毒性。本文全面综述了茄属植物糖苷生物碱及其苷元的生物活性，特别侧重于比较它们的生物活性，包括它们的抗癌、抗胆固醇、抗菌、抗炎、镇痛和解热作用、毒性以及主要茄属糖苷生物碱的协同作用，这与它们各自的分子结构差异有关。
