Clinic-University Hospital, University of Valencia, Spain.
Eur J Intern Med. 2011 Apr;22(2):177-81. doi: 10.1016/j.ejim.2010.12.011. Epub 2011 Jan 14.
We aim to study the prevalence of metabolic syndrome (MS), hypertension and diabetes, and their relationship to cardiovascular disease in subjects with hypertriglyceridemia.
This is an observational cross-sectional study, uncontrolled and multicentre study. Selected subjects were patients with hypertriglyceridemia (triglycerides, TG, ≥ 200 mg/dl) visited in the Lipid Units of the Spanish Arteriosclerosis Society who met the inclusion criteria. Prevalence of MS (ATPIII and IDF criteria, MS-ATPIII or MS-IDF), hypertension and diabetes were studied. The presence of cardiovascular disease (CVD) was also determined.
The results showed that individuals referred for hypertriglyceridemia had a high prevalence of MS-ATPIII 79.6% and MS-IDF 75.2%. The prevalence of MS was independent of plasma triglyceride levels. The prevalence of hypertension and diabetes were 50.9% and 33.5%, respectively. The prevalence of diabetes was double than in the general population. The prevalence of CVD was 14.6%. 95.9% of CVD events were found in patients with MS-ATPIII and only 4.1% in the group without MS-ATPIII, significant differences.
Hypertriglyceridemia is associated to the metabolic syndrome and diabetes, as well as the risk of CVD, independently of the levels of triglycerides. Hypertriglyceridemia may be an important marker in the screening of these severe metabolic and vascular abnormalities.
我们旨在研究高甘油三酯血症患者中代谢综合征（MS）、高血压和糖尿病的患病率及其与心血管疾病的关系。
这是一项观察性横断面研究，为非对照和多中心研究。入选的受试者为在西班牙动脉粥样硬化学会的血脂科就诊的高甘油三酯血症（甘油三酯，TG，≥200mg/dl）患者，符合纳入标准。研究了 MS（ATPIII 和 IDG 标准、MS-ATPIII 或 MS-IDF）、高血压和糖尿病的患病率。还确定了心血管疾病（CVD）的存在。
结果表明，因高甘油三酯血症就诊的个体存在高 MS-ATPIII（79.6%）和 MS-IDF（75.2%）患病率。MS 的患病率与血浆甘油三酯水平无关。高血压和糖尿病的患病率分别为 50.9%和 33.5%。糖尿病的患病率是一般人群的两倍。CVD 的患病率为 14.6%。95.9%的 CVD 事件发生在 MS-ATPIII 患者中，仅 4.1%发生在无 MS-ATPIII 组中，差异显著。
高甘油三酯血症与代谢综合征和糖尿病以及 CVD 风险相关，与甘油三酯水平无关。高甘油三酯血症可能是筛查这些严重代谢和血管异常的重要标志物。
