Unité 02 (rez-de-chaussée), service de cardiologie B, bâtiment H1, CHU Rangueil, TSA 50032, 31059 Toulouse cedex 9, France.
Arch Cardiovasc Dis. 2011 Feb;104(2):104-14. doi: 10.1016/j.acvd.2010.12.002.
The AntiPlatelet Therapy Observational Registry (APTOR) was a prospective observational study of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) in France, Spain, and the UK.
To evaluate patterns of ACS healthcare use, focusing on APTOR results from France.
Consecutive presenting ACS patients requiring PCI were recruited between January and August 2007. Treatments and outcomes were recorded from the qualifying ACS event to 12 months follow-up.
In France, qualifying diagnosis was unstable angina/non-ST-segment elevation myocardial infarction (UA/NSTEMI) in 255(53%) patients and ST-segment elevation myocardial infarction (STEMI) in 228(47%)patients. Ninety-six percent underwent PCI with stent implantation. Drug eluting stents were used less frequently in France(22%) than Spain (54%) or the UK (42%). In France, antiplatelets were more frequently received in the ambulance (21%); a 200-299mg aspirin-loading dose was most frequently received (50%) and more than a third of patients received a clopidogrel-loading dose of over 300mg (34%). At 12 months in France, 86% were still receiving aspirin, 75% clopidogrel, and 73% combination treatment.
There was considerable country-variation in ACS management. These results provide a benchmark of physician practice to compare with guidelines.
抗血小板治疗观察性登记研究（APTOR）是一项针对法国、西班牙和英国接受经皮冠状动脉介入治疗（PCI）的急性冠状动脉综合征（ACS）患者的前瞻性观察性研究。
评估 ACS 医疗保健的使用模式，重点关注 APTOR 在法国的结果。
2007 年 1 月至 8 月期间连续纳入需要 PCI 的初发 ACS 患者。从符合条件的 ACS 事件到 12 个月随访记录治疗和结局。
在法国，符合条件的诊断为不稳定型心绞痛/非 ST 段抬高型心肌梗死（UA/NSTEMI）的患者占 255 例（53%），ST 段抬高型心肌梗死（STEMI）的患者占 228 例（47%）。96%的患者接受了 PCI 伴支架植入。法国的药物洗脱支架使用率低于西班牙（54%）和英国（42%）。在法国，抗血小板药物更频繁地在救护车上使用（21%）；最常接受 200-299mg 阿司匹林负荷剂量（50%），超过三分之一的患者接受超过 300mg 的氯吡格雷负荷剂量（34%）。在法国，12 个月时，86%的患者仍在接受阿司匹林治疗，75%的患者接受氯吡格雷治疗，73%的患者接受联合治疗。
ACS 管理存在相当大的国家差异。这些结果为比较指南提供了医生实践的基准。
