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Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.Importin beta 在免疫激活的肥大细胞中 LysRS-Ap(4)A 途径的调节中发挥重要作用。
Mol Cell Biol. 2011 May;31(10):2111-21. doi: 10.1128/MCB.01159-10. Epub 2011 Mar 14.
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Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells.四磷酸二腺苷水解酶是免疫激活肥大细胞转录调控网络的一部分。
Mol Cell Biol. 2008 Sep;28(18):5777-84. doi: 10.1128/MCB.00106-08. Epub 2008 Jul 21.
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LysRS serves as a key signaling molecule in the immune response by regulating gene expression.赖氨酰-tRNA合成酶（LysRS）通过调节基因表达，在免疫反应中充当关键信号分子。
Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.
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Nonconventional involvement of LysRS in the molecular mechanism of USF2 transcriptional activity in FcepsilonRI-activated mast cells.赖氨酰-tRNA合成酶（LysRS）在FcεRI激活的肥大细胞中对USF2转录活性分子机制的非常规参与。
Mol Cell Biol. 2005 Oct;25(20):8904-12. doi: 10.1128/MCB.25.20.8904-8912.2005.
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Structural switch of lysyl-tRNA synthetase between translation and transcription.赖氨酸 tRNA 合成酶在翻译和转录之间的结构转换。
Mol Cell. 2013 Jan 10;49(1):30-42. doi: 10.1016/j.molcel.2012.10.010. Epub 2012 Nov 15.
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The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.赖氨酰 - tRNA合成酶和Ap4A作为FcepsilonRI激活的肥大细胞中MITF活性信号调节因子的功能。
Immunity. 2004 Feb;20(2):145-51. doi: 10.1016/s1074-7613(04)00020-2.
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MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway.MRGPRX2 信号通路涉及赖氨酰 tRNA 合成酶和 MITF 通路。
Front Immunol. 2023 May 10;14:1154108. doi: 10.3389/fimmu.2023.1154108. eCollection 2023.
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Chapter 1: The physiological role of lysyl tRNA synthetase in the immune system.第1章：赖氨酰tRNA合成酶在免疫系统中的生理作用。
Adv Immunol. 2009;103:1-27. doi: 10.1016/S0065-2776(09)03001-6.
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Mutation in KARS: A novel mechanism for severe anaphylaxis.KARS 突变：严重过敏反应的新机制。
J Allergy Clin Immunol. 2021 May;147(5):1855-1864.e9. doi: 10.1016/j.jaci.2020.12.637. Epub 2020 Dec 29.
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Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins.赖氨酰 - tRNA合成酶生成的赖氨酰 - 腺苷酸是组氨酸三联体核苷酸结合蛋白的一种底物。
J Biol Chem. 2007 Feb 16;282(7):4719-4727. doi: 10.1074/jbc.M610530200. Epub 2006 Dec 8.
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Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation.赖氨酰 - tRNA合成酶1通过自噬相关分泌和炎症促进动脉粥样硬化的发生。
Sci Rep. 2025 Apr 1;15(1):11099. doi: 10.1038/s41598-025-96046-y.
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AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.EPRS1 的 AKT 依赖性核定位激活乳腺癌细胞中的 PARP1。
Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2303642121. doi: 10.1073/pnas.2303642121. Epub 2024 Jul 16.
3
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.多模态共翻译相互作用指导人多 tRNA 合成酶复合物的组装。
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205669119. doi: 10.1073/pnas.2205669119. Epub 2022 Aug 29.
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Aminoacyl-tRNA Synthetase: A Non-Negligible Molecule in RNA Viral Infection.氨酰-tRNA合成酶：RNA病毒感染中不可忽视的分子
Viruses. 2022 Mar 15;14(3):613. doi: 10.3390/v14030613.
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The pLysRS-ApA Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State.肥大细胞中 pLysRS-ApA 途径调控宿主防御向病理性状态的转变。
Int J Mol Sci. 2021 May 25;22(11):5620. doi: 10.3390/ijms22115620.
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Bi-allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease.双等位基因 KARS1 致病性变异影响细胞质和线粒体同工型的功能，与进行性多系统疾病相关。
Hum Mutat. 2021 Jun;42(6):745-761. doi: 10.1002/humu.24210. Epub 2021 May 11.
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The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis.小眼畸形相关转录因子（MiTF）在正常和病理性造血过程中被低估的作用。
Cell Biosci. 2021 Jan 13;11(1):18. doi: 10.1186/s13578-021-00529-0.
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Second messenger ApA polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.第二信使 ApA 将靶蛋白 HINT1 聚合，以在 FcεRI 激活的肥大细胞中转导信号。
Nat Commun. 2019 Oct 11;10(1):4664. doi: 10.1038/s41467-019-12710-8.
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ApA Regulates Directional Mobility and Antigen Presentation in Dendritic Cells.ApA调节树突状细胞的定向迁移和抗原呈递。
iScience. 2019 Jun 28;16:524-534. doi: 10.1016/j.isci.2019.05.045. Epub 2019 Jun 4.
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HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication.HIV-1利用动态多氨酰-tRNA合成酶复合物增强病毒复制。
J Virol. 2017 Oct 13;91(21). doi: 10.1128/JVI.01240-17. Print 2017 Nov 1.
本文引用的文献
1
Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation.Nudix 基序 2 在人乳腺癌中的表达：与细胞增殖相关的强预后因子。
Int J Cancer. 2011 Apr 15;128(8):1770-82. doi: 10.1002/ijc.25505.
2
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown.通过靶向 cAMP 分解为细胞内信号传递提供基础。
Trends Biochem Sci. 2010 Feb;35(2):91-100. doi: 10.1016/j.tibs.2009.09.007. Epub 2009 Oct 26.
3
LysRS serves as a key signaling molecule in the immune response by regulating gene expression.赖氨酰-tRNA合成酶（LysRS）通过调节基因表达，在免疫反应中充当关键信号分子。
Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.
4
Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.维甲酸在HL-60细胞分化过程中诱导Raf1在细胞核内积聚。
Exp Cell Res. 2009 Aug 1;315(13):2241-8. doi: 10.1016/j.yexcr.2009.03.004. Epub 2009 Mar 17.
5
Measurement of cytoplasmic to nuclear translocation.细胞质到细胞核转位的测量。
Curr Protoc Cytom. 2009 Jan;Chapter 9:9.28.1-9.28.15. doi: 10.1002/0471142956.cy0928s47.
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Identification and characterization of a general nuclear translocation signal in signaling proteins.信号蛋白中通用核转位信号的鉴定与表征
Mol Cell. 2008 Sep 26;31(6):850-61. doi: 10.1016/j.molcel.2008.08.007. Epub 2008 Sep 4.
7
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.AIMP2/p38是多tRNA合成酶复合体的支架蛋白，它通过p53对基因毒性应激作出反应。
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11206-11. doi: 10.1073/pnas.0800297105. Epub 2008 Aug 11.
8
Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells.四磷酸二腺苷水解酶是免疫激活肥大细胞转录调控网络的一部分。
Mol Cell Biol. 2008 Sep;28(18):5777-84. doi: 10.1128/MCB.00106-08. Epub 2008 Jul 21.
9
Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells--important role for nuclear thioredoxin-1.核氧化还原信号传导对于内皮细胞凋亡抑制至关重要——核硫氧还蛋白-1的重要作用。
Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2325-31. doi: 10.1161/ATVBAHA.107.149419. Epub 2007 Sep 6.
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Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster.黑腹果蝇双（5'-核苷基）-四磷酸酶（不对称）的特性分析。
Int J Biochem Cell Biol. 2007;39(5):943-54. doi: 10.1016/j.biocel.2007.01.017. Epub 2007 Jan 24.
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