2005 年至 2009 年期间，在加拿大多伦多分离的耐甲氧西林金黄色葡萄球菌中，qacA、qacB 和 smr 三种抗消毒剂基因的分布情况。
Distribution of antiseptic resistance genes qacA, qacB, and smr in methicillin-resistant Staphylococcus aureus isolated in Toronto, Canada, from 2005 to 2009.
机构信息
Infectious Disease Research Center, Laval University, 2750 Laurier Blvd., Quebec City, Quebec G1V 4G2, Canada.
出版信息
Antimicrob Agents Chemother. 2011 Jun;55(6):2999-3001. doi: 10.1128/AAC.01707-10. Epub 2011 Mar 14.
Abstract
Decreased susceptibility to chlorhexidine gluconate (CHDN) in methicillin-resistant Staphylococcus aureus (MRSA) is associated with the qacA, qacB, and smr genes, encoding efflux pumps. A total of 334 MRSA isolates were collected from two Canadian intensive care units between 2005 and 2009. We identified the qacAB genes in 7 strains (2%; 2 qacA genes and 5 qacB genes) and the smr gene in 23 (7%) strains. CHDN minimal bactericidal concentrations were slightly higher for strains harboring smr genes.
摘要
耐氯己定葡萄糖酸盐（CHDN）的金黄色葡萄球菌（MRSA）的易感性降低与编码外排泵的 qacA、qacB 和 smr 基因有关。2005 年至 2009 年间，我们从加拿大的两个重症监护病房共收集了 334 株耐甲氧西林金黄色葡萄球菌（MRSA）。我们在 7 株（2%；2 个 qacA 基因和 5 个 qacB 基因）和 23 株（7%）菌株中发现了 qacAB 基因和 smr 基因。携带 smr 基因的菌株对 CHDN 的最小杀菌浓度略高。
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