牛呼吸道疾病多杀巴斯德菌中大环内酯类、三烷酰胺类和林可酰胺类耐药的分子基础。
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
机构信息
Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2475-7. doi: 10.1128/AAC.00092-11. Epub 2011 Mar 14.
Abstract
The mechanism of macrolide-triamilide resistance in Pasteurella multocida has been unknown. During whole-genome sequencing of a multiresistant bovine P. multocida isolate, three new resistance genes, the rRNA methylase gene erm(42), the macrolide transporter gene msr(E), and the macrolide phosphotransferase gene mph(E), were detected. The three genes were PCR amplified, cloned into suitable plasmid vectors, and shown to confer either macrolide-lincosamide resistance [erm(42)] or macrolide-triamilide resistance [msr(E)-mph(E)] in macrolide-susceptible Escherichia coli and P. multocida hosts.
摘要
多杀巴斯德氏菌中大环内酯-三嗪酰胺耐药的机制尚不清楚。在对一株多耐药牛源多杀巴斯德氏菌的全基因组测序过程中，发现了三个新的耐药基因，核糖体 RNA 甲基化酶基因 erm(42)、大环内酯类转运蛋白基因 msr(E)和大环内酯类磷酸转移酶基因 mph(E)。这三个基因被 PCR 扩增，克隆到合适的质粒载体中，并在大环内酯类敏感的大肠杆菌和多杀巴斯德氏菌宿主中显示出对大环内酯-林可酰胺类（erm(42)）或大环内酯-三嗪酰胺类（msr(E)-mph(E)）的耐药性。
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